STRINGSTRING
RFC4 RFC4 RAD9A RAD9A SIRT6 SIRT6 CHEK1 CHEK1 WRN WRN RAD1 RAD1 RMI2 RMI2 RPA3 RPA3 RPA1 RPA1 RBBP8 RBBP8 CLSPN CLSPN BRCA1 BRCA1 RFC5 RFC5 HUS1 HUS1 BRIP1 BRIP1 DNA2 DNA2 NBN NBN PPP4R2 PPP4R2 RHNO1 RHNO1 TOP3A TOP3A MRE11 MRE11 TIPIN TIPIN RAD50 RAD50 RAD17 RAD17 RFC2 RFC2 TOPBP1 TOPBP1 PPP4C PPP4C ATRIP ATRIP KAT5 KAT5 RFC3 RFC3 BARD1 BARD1 EXO1 EXO1 RPA2 RPA2 TIMELESS TIMELESS CDK2 CDK2 BLM BLM CCNA1 CCNA1 RAD9B RAD9B RMI1 RMI1 ATR ATR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFC4Replication factor C subunit 4. (364 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (327 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
WRNWRN RecQ like helicase. (1466 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
RMI2RecQ-mediated genome instability protein 2. (150 aa)
RPA3Replication protein A3. (121 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
CLSPNClaspin. (1325 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa)
RFC5Replication factor C subunit 5. (343 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (289 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (978 aa)
DNA2DNA replication helicase/nuclease 2. (1084 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (414 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1032 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (320 aa)
RAD50Zinc-hook domain-containing protein. (1358 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (711 aa)
RFC2Replication factor C subunit 2 isoform 1. (352 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1583 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
ATRIPATR interacting protein. (823 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
EXO1Exonuclease 1. (836 aa)
RPA2RPA_C domain-containing protein. (270 aa)
TIMELESSTimeless circadian regulator. (1206 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
BLMBLM RecQ like helicase. (1432 aa)
CCNA1Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (398 aa)
RMI1RecQ mediated genome instability 1. (623 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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