STRINGSTRING
RPA2 RPA2 PARP2 PARP2 MNAT1 MNAT1 XPA XPA CHD1L CHD1L CUL4B CUL4B CETN2 CETN2 DDB1 DDB1 GTF2H1 GTF2H1 KXD1 KXD1 SUMO2 SUMO2 PARP1 PARP1 RPA3 RPA3 RPA1 RPA1 ERCC5 ERCC5 ERCC2 ERCC2 CCNH CCNH GTF2H2 GTF2H2 XPC XPC DDB2 DDB2 SUMO3 SUMO3 GTF2H3 GTF2H3 ERCC3 ERCC3 RAD23A RAD23A RPS27A RPS27A RBX1 RBX1 RNF111 RNF111 LOC100737265 LOC100737265 UBC UBC CDK7 CDK7 UBE2V2 UBE2V2 CUL4A CUL4A UBE2N UBE2N GTF2H5 GTF2H5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA2RPA_C domain-containing protein. (270 aa)
PARP2Poly [ADP-ribose] polymerase. (567 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
XPAXPA, DNA damage recognition and repair factor. (310 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (901 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1056 aa)
CETN2Centrin 2. (234 aa)
DDB1Damage specific DNA binding protein 1. (1139 aa)
GTF2H1General transcription factor IIH subunit 1. (674 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
SUMO2Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] (95 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
RPA3Replication protein A3. (121 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ERCC5ERCC excision repair 5, endonuclease. (1199 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
CCNHCyclin-H isoform 1; Belongs to the cyclin family. (328 aa)
GTF2H2VWFA domain-containing protein. (613 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (1018 aa)
DDB2DNA damage-binding protein 2 isoform WT. (448 aa)
SUMO3Small ubiquitin-related modifier. (101 aa)
GTF2H3General transcription factor IIH subunit 3 isoform a. (321 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (801 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (417 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
RNF111Ring finger protein 111. (992 aa)
LOC100737265Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (361 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa)
CUL4ACullin 4A; Belongs to the cullin family. (712 aa)
UBE2NUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (147 aa)
GTF2H5Uncharacterized protein. (88 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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