STRINGSTRING
POLR2F POLR2F COPS7A COPS7A F1SBB8_PIG F1SBB8_PIG COPS2 COPS2 MNAT1 MNAT1 XPA XPA USP7 USP7 COPS4 COPS4 ERCC6 ERCC6 CUL4B CUL4B DDB1 DDB1 PRPF19 PRPF19 GTF2H1 GTF2H1 KXD1 KXD1 COPS8 COPS8 EP300 EP300 POLR2B POLR2B POLR2A POLR2A POLR2K POLR2K POLR2E POLR2E AQR AQR PPIE PPIE COPS7B COPS7B ERCC2 ERCC2 LOC102162880 LOC102162880 CCNH CCNH GPS1 GPS1 GTF2H2 GTF2H2 COPS5 COPS5 COPS6 COPS6 POLR2D POLR2D POLR2I POLR2I GTF2H3 GTF2H3 ERCC3 ERCC3 RPS27A RPS27A RBX1 RBX1 UVSSA UVSSA COPS3 COPS3 UBC UBC ZNF830 ZNF830 POLR2J POLR2J CUL4A CUL4A POLR2G POLR2G POLR2H POLR2H GTF2H5 GTF2H5 XAB2 XAB2 ERCC8 ERCC8 CDK7 CDK7 TCEA1 TCEA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR2FRNA polymerase II subunit F. (127 aa)
COPS7ACOP9 signalosome subunit 7A. (296 aa)
F1SBB8_PIGUncharacterized protein. (100 aa)
COPS2COP9 signalosome subunit 2. (450 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
XPAXPA, DNA damage recognition and repair factor. (310 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1109 aa)
COPS4COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] (406 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1462 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1056 aa)
DDB1Damage specific DNA binding protein 1. (1139 aa)
PRPF19Pre-mRNA-processing factor 19. (504 aa)
GTF2H1General transcription factor IIH subunit 1. (674 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
COPS8COP9 signalosome subunit 8. (212 aa)
EP300E1A binding protein p300. (2420 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1251 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1942 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1492 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (310 aa)
COPS7BCOP9 signalosome subunit 7B. (280 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
LOC102162880Uncharacterized protein. (256 aa)
CCNHCyclin-H isoform 1; Belongs to the cyclin family. (328 aa)
GPS1G protein pathway suppressor 1. (664 aa)
GTF2H2VWFA domain-containing protein. (613 aa)
COPS5COP9 signalosome subunit 5. (409 aa)
COPS6COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (358 aa)
POLR2DRNA polymerase II subunit D. (184 aa)
POLR2IDNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). (125 aa)
GTF2H3General transcription factor IIH subunit 3 isoform a. (321 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (801 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
UVSSAUV stimulated scaffold protein A. (821 aa)
COPS3COP9 signalosome subunit 3. (426 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
ZNF830Zinc finger protein 830. (367 aa)
POLR2JRNA_pol_L_2 domain-containing protein. (164 aa)
CUL4ACullin 4A; Belongs to the cullin family. (712 aa)
POLR2GRNA polymerase II subunit G. (231 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (153 aa)
GTF2H5Uncharacterized protein. (88 aa)
XAB2XPA binding protein 2. (858 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (361 aa)
TCEA1Transcription elongation factor A1. (293 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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