(17 nodes) IL-6-type cytokine receptor ligand interactions network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTF1	Cardiotrophin 1. (202 aa)
	IL31	Uncharacterized protein. (138 aa)
	OSM	Oncostatin M. (234 aa)
	IL11RA	Uncharacterized protein. (422 aa)
	CNTFR	Ciliary neurotrophic factor receptor. (438 aa)
	CLCF1	Uncharacterized protein. (484 aa)
	OSMR	Oncostatin-M-specific receptor subunit beta isoform X1. (977 aa)
	IL31RA	Interleukin-31 receptor subunit alpha isoform 2. (717 aa)
	LIFR	LIF receptor subunit alpha. (1170 aa)
	JAK2	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
	IL6ST	Interleukin 6 signal transducer. (938 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	TYK2	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa)
	LIF	Leukemia inhibitory factor isoform X1. (202 aa)
	IL11	Interleukin 11. (199 aa)
	CRLF1	Cytokine receptor like factor 1. (421 aa)
	CNTF	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity). (619 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCF1	CNTF	ENSSSCP00000013732	ENSSSCP00000069014	Uncharacterized protein.	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	0.499
CLCF1	CNTFR	ENSSSCP00000013732	ENSSSCP00000011703	Uncharacterized protein.	Ciliary neurotrophic factor receptor.	0.962
CLCF1	CRLF1	ENSSSCP00000013732	ENSSSCP00000042619	Uncharacterized protein.	Cytokine receptor like factor 1.	0.958
CLCF1	CTF1	ENSSSCP00000013732	ENSSSCP00000008302	Uncharacterized protein.	Cardiotrophin 1.	0.461
CLCF1	IL6ST	ENSSSCP00000013732	ENSSSCP00000030641	Uncharacterized protein.	Interleukin 6 signal transducer.	0.907
CLCF1	JAK1	ENSSSCP00000013732	ENSSSCP00000032415	Uncharacterized protein.	Tyrosine-protein kinase.	0.511
CLCF1	JAK2	ENSSSCP00000013732	ENSSSCP00000029236	Uncharacterized protein.	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.527
CLCF1	LIF	ENSSSCP00000013732	ENSSSCP00000036194	Uncharacterized protein.	Leukemia inhibitory factor isoform X1.	0.400
CLCF1	LIFR	ENSSSCP00000013732	ENSSSCP00000029041	Uncharacterized protein.	LIF receptor subunit alpha.	0.942
CLCF1	OSMR	ENSSSCP00000013732	ENSSSCP00000017855	Uncharacterized protein.	Oncostatin-M-specific receptor subunit beta isoform X1.	0.499
CLCF1	TYK2	ENSSSCP00000013732	ENSSSCP00000035640	Uncharacterized protein.	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.521
CNTF	CLCF1	ENSSSCP00000069014	ENSSSCP00000013732	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Uncharacterized protein.	0.499
CNTF	CNTFR	ENSSSCP00000069014	ENSSSCP00000011703	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Ciliary neurotrophic factor receptor.	0.929
CNTF	CRLF1	ENSSSCP00000069014	ENSSSCP00000042619	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Cytokine receptor like factor 1.	0.499
CNTF	IL6ST	ENSSSCP00000069014	ENSSSCP00000030641	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Interleukin 6 signal transducer.	0.624
CNTF	JAK1	ENSSSCP00000069014	ENSSSCP00000032415	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Tyrosine-protein kinase.	0.516
CNTF	JAK2	ENSSSCP00000069014	ENSSSCP00000029236	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]	0.516
CNTF	LIFR	ENSSSCP00000069014	ENSSSCP00000029041	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	LIF receptor subunit alpha.	0.529
CNTF	TYK2	ENSSSCP00000069014	ENSSSCP00000035640	Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy (By similarity).	Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.516
CNTFR	CLCF1	ENSSSCP00000011703	ENSSSCP00000013732	Ciliary neurotrophic factor receptor.	Uncharacterized protein.	0.962