STRINGSTRING
CSNK2A1 CSNK2A1 PRKAG1 PRKAG1 CDK2 CDK2 TAF11 TAF11 BLM BLM TAF4B TAF4B PLK3 PLK3 PRKAB2 PRKAB2 HIPK1 HIPK1 TP53RK TP53RK CCNA1 CCNA1 RAD9B RAD9B MAPKAPK5 MAPKAPK5 TAF5 TAF5 RMI1 RMI1 TAF3 TAF3 ATR ATR RFC4 RFC4 RAD9A RAD9A STK11 STK11 KXD1 KXD1 CHEK1 CHEK1 WRN WRN PRKAG2 PRKAG2 RAD1 RAD1 TAF15 TAF15 CDK5R1 CDK5R1 CDK5 CDK5 RMI2 RMI2 TAF10 TAF10 SUPT16H SUPT16H RPA3 RPA3 RPA1 RPA1 HIPK2 HIPK2 NOC2L NOC2L TPX2 TPX2 SSRP1 SSRP1 PIN1 PIN1 TAF1 TAF1 TAF7 TAF7 TAF4 TAF4 CSNK2B CSNK2B TAF2 TAF2 MAPK11 MAPK11 RBBP8 RBBP8 BRCA1 BRCA1 AURKA AURKA DYRK2 DYRK2 RFC5 RFC5 CHEK2 CHEK2 HUS1 HUS1 NUAK1 NUAK1 CSNK2A2 CSNK2A2 TAF12 TAF12 BRIP1 BRIP1 DNA2 DNA2 NBN NBN RPS27A RPS27A TP53 TP53 TAF9B TAF9B TAF6 TAF6 RHNO1 RHNO1 MDM2 MDM2 TOP3A TOP3A MRE11 MRE11 TP53INP1 TP53INP1 PRKAA2 PRKAA2 RAD50 RAD50 RAD17 RAD17 RFC2 RFC2 TOPBP1 TOPBP1 TAF13 TAF13 UBC UBC TAF7L TAF7L TAF9 TAF9 ATRIP ATRIP MAPK14 MAPK14 KAT5 KAT5 RFC3 RFC3 BARD1 BARD1 EXO1 EXO1 RPA2 RPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
TAF11Transcription initiation factor TFIID subunit 11 isoform 1. (211 aa)
BLMBLM RecQ like helicase. (1432 aa)
TAF4BTATA-box binding protein associated factor 4b. (869 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa)
TP53RKTP53 regulating kinase. (255 aa)
CCNA1Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (398 aa)
MAPKAPK5Protein kinase domain-containing protein. (543 aa)
TAF5Transcription initiation factor TFIID subunit 5 isoform 1. (800 aa)
RMI1RecQ mediated genome instability 1. (623 aa)
TAF3TATA-box binding protein associated factor 3. (929 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
RFC4Replication factor C subunit 4. (364 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
WRNWRN RecQ like helicase. (1466 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
TAF15Taf15. (602 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (315 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
RMI2RecQ-mediated genome instability protein 2. (150 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1083 aa)
RPA3Replication protein A3. (121 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
HIPK2Homeodomain interacting protein kinase 2. (1208 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (713 aa)
TPX2TPX2 microtubule nucleation factor. (747 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (704 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
TAF1Transcription initiation factor TFIID subunit. (2001 aa)
TAF7Transcription initiation factor TFIID subunit 7. (349 aa)
TAF4TATA-box binding protein associated factor 4. (1031 aa)
CSNK2BCasein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa)
TAF2TATA-box binding protein associated factor 2. (1251 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa)
AURKAAurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] (408 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa)
RFC5Replication factor C subunit 5. (343 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X4. (553 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (289 aa)
NUAK1NUAK family kinase 1. (666 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
TAF12Transcription initiation factor TFIID subunit 12 isoform X1. (213 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (978 aa)
DNA2DNA replication helicase/nuclease 2. (1084 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (273 aa)
TAF6TATA-box binding protein associated factor 6. (705 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1032 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
RAD50Zinc-hook domain-containing protein. (1358 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (711 aa)
RFC2Replication factor C subunit 2 isoform 1. (352 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1583 aa)
TAF13Uncharacterized protein. (132 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
TAF7LTATA-box binding protein associated factor 7 like. (468 aa)
TAF9Transcription initiation factor TFIID subunit 9. (265 aa)
ATRIPATR interacting protein. (823 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
EXO1Exonuclease 1. (836 aa)
RPA2RPA_C domain-containing protein. (270 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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