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| | PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa) |
| | IRAK4 | Protein kinase domain-containing protein. (459 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa) |
| | FYN | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa) |
| | IL33 | Interleukin 33. (276 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa) |
| | STRN | Striatin isoform X1. (809 aa) |
| | AREG | Amphiregulin long form. (247 aa) |
| | KL | Klotho. (1011 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa) |
| | CD80 | CD80 molecule. (297 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (691 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1201 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | KLB | Klotho beta. (1044 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1342 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | TRAT1 | T cell receptor associated transmembrane adaptor 1. (181 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | ICOS | IGv domain-containing protein. (209 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa) |
| | FLT3 | Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa) |
| | CD86 | T-lymphocyte activation antigen CD86 isoform 1. (337 aa) |
| | IER3 | Immediate early response 3. (214 aa) |
| | GAB1 | GRB2 associated binding protein 1. (723 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (820 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (903 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | NRG3 | Neuregulin 3. (718 aa) |
| | A0A286ZJU7_PIG | Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (235 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) |
| | BTC | EGF-like domain-containing protein. (342 aa) |
| | CD19 | CD19 molecule. (645 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | NRG1 | Neuregulin 1. (712 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (477 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | RHOG | Uncharacterized protein. (394 aa) |
| | GAB2 | GRB2 associated binding protein 2. (740 aa) |
| | IRS2 | Insulin receptor substrate 2. (1092 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | IL1RAP | Interleukin-1 receptor accessory protein isoform 3. (685 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (550 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (614 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (573 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) |
| | FGF9 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa) |
| | PIK3R2 | Uncharacterized protein. (772 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | RAC1 | Rac family small GTPase 1. (186 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | PIK3AP1 | Phosphoinositide-3-kinase adaptor protein 1. (905 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | EREG | Epiregulin. (168 aa) |
| | NRG2 | Neuregulin 2. (858 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (659 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa) |
| | RAC2 | Rac family small GTPase 2. (217 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (476 aa) |
