(31 nodes) Activation of the pre-replicative complex network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	RPA2	RPA_C domain-containing protein. (270 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
	GMNN	Geminin DNA replication inhibitor. (215 aa)
	ORC3	Origin recognition complex subunit 3. (758 aa)
	POLE3	Uncharacterized protein. (171 aa)
	MCM8	MCM domain-containing protein; Belongs to the MCM family. (831 aa)
	POLA2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (584 aa)
	ORC5	Origin recognition complex subunit 5 isoform 1. (446 aa)
	ORC4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
	ORC2	Origin recognition complex subunit 2. (578 aa)
	CDC6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
	MCM3	DNA helicase; Belongs to the MCM family. (808 aa)
	RPA3	Replication protein A3. (121 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	ORC1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (865 aa)
	CDC45	Cell division cycle 45. (598 aa)
	MCM6	DNA helicase; Belongs to the MCM family. (821 aa)
	DBF4	DBF4-type domain-containing protein. (675 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (930 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (882 aa)
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
	CDT1	PI-PLC Y-box domain-containing protein. (815 aa)
	PRIM2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
	MCM10	Minichromosome maintenance 10 replication initiation factor. (943 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (733 aa)
	ORC6	Origin recognition complex subunit 6. (287 aa)
	CDC7	Cell division cycle 7-related protein kinase isoform X1. (576 aa)
	POLA1	DNA polymerase. (1652 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (138 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	CDC6	ENSSSCP00000030798	ENSSSCP00000018515	Cell division cycle 45.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.958
CDC45	CDC7	ENSSSCP00000030798	ENSSSCP00000068885	Cell division cycle 45.	Cell division cycle 7-related protein kinase isoform X1.	0.847
CDC45	CDK2	ENSSSCP00000030798	ENSSSCP00000000392	Cell division cycle 45.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.820
CDC45	CDT1	ENSSSCP00000030798	ENSSSCP00000052950	Cell division cycle 45.	PI-PLC Y-box domain-containing protein.	0.982
CDC45	DBF4	ENSSSCP00000030798	ENSSSCP00000038261	Cell division cycle 45.	DBF4-type domain-containing protein.	0.925
CDC45	GMNN	ENSSSCP00000030798	ENSSSCP00000001166	Cell division cycle 45.	Geminin DNA replication inhibitor.	0.632
CDC45	MCM10	ENSSSCP00000030798	ENSSSCP00000059636	Cell division cycle 45.	Minichromosome maintenance 10 replication initiation factor.	0.998
CDC45	MCM2	ENSSSCP00000030798	ENSSSCP00000041765	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.998
CDC45	MCM3	ENSSSCP00000030798	ENSSSCP00000019950	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.995
CDC45	MCM4	ENSSSCP00000030798	ENSSSCP00000047671	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.998
CDC45	MCM5	ENSSSCP00000030798	ENSSSCP00000063270	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.996
CDC45	MCM6	ENSSSCP00000030798	ENSSSCP00000037726	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.997
CDC45	MCM7	ENSSSCP00000030798	ENSSSCP00000050669	Cell division cycle 45.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.996
CDC45	MCM8	ENSSSCP00000030798	ENSSSCP00000007509	Cell division cycle 45.	MCM domain-containing protein; Belongs to the MCM family.	0.927
CDC45	ORC1	ENSSSCP00000030798	ENSSSCP00000027246	Cell division cycle 45.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.958
CDC45	ORC2	ENSSSCP00000030798	ENSSSCP00000017055	Cell division cycle 45.	Origin recognition complex subunit 2.	0.911
CDC45	ORC3	ENSSSCP00000030798	ENSSSCP00000004650	Cell division cycle 45.	Origin recognition complex subunit 3.	0.874
CDC45	ORC4	ENSSSCP00000030798	ENSSSCP00000016611	Cell division cycle 45.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.887
CDC45	ORC5	ENSSSCP00000030798	ENSSSCP00000016358	Cell division cycle 45.	Origin recognition complex subunit 5 isoform 1.	0.942
CDC45	ORC6	ENSSSCP00000030798	ENSSSCP00000065897	Cell division cycle 45.	Origin recognition complex subunit 6.	0.867