STRINGSTRING
CDKN2C CDKN2C MNAT1 MNAT1 CDK2 CDK2 CDKN2B CDKN2B CCNE2 CCNE2 E2F5 E2F5 LYN LYN E2F1 E2F1 RB1 RB1 KXD1 KXD1 PPP2CA PPP2CA SKP2 SKP2 CDK4 CDK4 JAK2 JAK2 SRC SRC CDK6 CDK6 A0A286ZHX0_PIG A0A286ZHX0_PIG CUL1 CUL1 RBL2 RBL2 P14ARF P14ARF TFDP1 TFDP1 E2F2 E2F2 PTK6 PTK6 E2F4 E2F4 CCNH CCNH CDKN1C CDKN1C RBL1 RBL1 CDKN1B CDKN1B SKP1 SKP1 RPS27A RPS27A CCND2 CCND2 ABL1 ABL1 TFDP2 TFDP2 E2F3 E2F3 CCND1 CCND1 CCND3 CCND3 UBC UBC PPP2R3B PPP2R3B PPP2CB PPP2CB CDK7 CDK7 CDKN1A CDKN1A CCNE1 CCNE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
E2F5E2F transcription factor 5. (344 aa)
LYNTyrosine-protein kinase. (512 aa)
E2F1E2F transcription factor 1. (435 aa)
RB1RB transcriptional corepressor 1. (938 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
SKP2S-phase kinase-associated protein 2 isoform 1. (436 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
SRCTyrosine-protein kinase. (559 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
A0A286ZHX0_PIGCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (117 aa)
CUL1Cullin 1; Belongs to the cullin family. (802 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
P14ARFANK_REP_REGION domain-containing protein. (159 aa)
TFDP1Transcription factor. (415 aa)
E2F2E2F transcription factor 2. (437 aa)
PTK6Tyrosine-protein kinase. (449 aa)
E2F4E2F transcription factor 4. (468 aa)
CCNHCyclin-H isoform 1; Belongs to the cyclin family. (328 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (262 aa)
RBL1RB transcriptional corepressor like 1. (1044 aa)
CDKN1Bp27Kip1. (198 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
CCND2G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (288 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
TFDP2Transcription factor. (447 aa)
E2F3E2F transcription factor 3. (466 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (331 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (576 aa)
PPP2CBSerine/threonine-protein phosphatase. (476 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (361 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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