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| | MCM4 | DNA helicase; Belongs to the MCM family. (882 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa) |
| | GMNN | Geminin DNA replication inhibitor. (215 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | PSME1 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa) |
| | PSMB11 | Proteasome subunit beta. (291 aa) |
| | PSMC1 | 26S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CCNE1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | ORC3 | Origin recognition complex subunit 3. (758 aa) |
| | POLE3 | Uncharacterized protein. (171 aa) |
| | PSMB7 | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa) |
| | CCNE2 | G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (380 aa) |
| | PSMA5 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (831 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | CCNA1 | Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5 isoform X1. (755 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (450 aa) |
| | RFC4 | Replication factor C subunit 4. (364 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (584 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa) |
| | CDC23 | Cell division cycle protein 23 homolog. (594 aa) |
| | PSMC2 | AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa) |
| | ORC5 | Origin recognition complex subunit 5 isoform 1. (446 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | ORC2 | Origin recognition complex subunit 2. (578 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | SKP2 | S-phase kinase-associated protein 2 isoform 1. (436 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (534 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (421 aa) |
| | POLD3 | Uncharacterized protein. (463 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (597 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | PSMF1 | Uncharacterized protein. (351 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (865 aa) |
| | RFC1 | Replication factor C subunit 1. (1141 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (471 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (802 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (223 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | A0A286ZS34_PIG | Uncharacterized protein. (179 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | CDC26 | Cell division cycle 26. (107 aa) |
| | GINS1 | DNA replication complex GINS protein PSF1. (196 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | RFC5 | Replication factor C subunit 5. (343 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (930 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | PSME4 | Proteasome activator complex subunit 4. (1843 aa) |
| | SKP1 | S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1084 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | ANAPC15 | Anaphase promoting complex subunit 15. (125 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (204 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | FZR1 | Fizzy and cell division cycle 20 related 1. (493 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | RBX1 | E3 ubiquitin-protein ligase RBX1. (108 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (351 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa) |
| | POLD1 | DNA polymerase. (1152 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (882 aa) |
| | CDT1 | PI-PLC Y-box domain-containing protein. (815 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (192 aa) |
| | LOC102160336 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | PSMB10 | Proteasome subunit beta. (296 aa) |
| | PSMA7 | Proteasome subunit alpha type. (267 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (85 aa) |
| | RFC2 | Replication factor C subunit 2 isoform 1. (352 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | POLD4 | Uncharacterized protein. (134 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa) |
| | UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (733 aa) |
| | PSMA2 | Proteasome endopeptidase complex. (243 aa) |
| | PSMC5 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa) |
| | ANAPC11 | RING-type domain-containing protein. (411 aa) |
| | PSMA4 | Proteasome subunit alpha type. (281 aa) |
| | ORC6 | Origin recognition complex subunit 6. (287 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | PSMA3 | Proteasome subunit alpha type. (275 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (419 aa) |
| | RFC3 | Replication factor C subunit 3 isoform 1. (356 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa) |
| | PSMB6 | Uncharacterized protein. (334 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (680 aa) |
| | LIG1 | DNA ligase. (916 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa) |
| | POLA1 | DNA polymerase. (1652 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (138 aa) |
| | RPA2 | RPA_C domain-containing protein. (270 aa) |
