STRINGSTRING
RFC5 RFC5 LOC100152135 LOC100152135 LOC100152878 LOC100152878 BLM BLM YWHAZ YWHAZ NSD2 NSD2 F1RWC9_PIG F1RWC9_PIG ABRAXAS1 ABRAXAS1 RAD9B RAD9B LOC100155267 LOC100155267 YWHAH YWHAH RMI1 RMI1 ATR ATR RFC4 RFC4 RAD9A RAD9A WEE1 WEE1 CDC25C CDC25C CHEK1 CHEK1 WRN WRN HERC2 HERC2 RAD1 RAD1 RMI2 RMI2 I3LAJ9_PIG I3LAJ9_PIG HIST1H2BD HIST1H2BD RPA3 RPA3 CCNB1 CCNB1 RPA1 RPA1 LOC100621389 LOC100621389 RBBP8 RBBP8 BABAM1 BABAM1 BRCA1 BRCA1 TP53BP1 TP53BP1 CHEK2 CHEK2 H2BC11 H2BC11 HUS1 HUS1 PIAS4 PIAS4 CDK1 CDK1 BRIP1 BRIP1 DNA2 DNA2 H2BU1 H2BU1 NBN NBN TP53 TP53 RHNO1 RHNO1 BABAM2 BABAM2 TOP3A TOP3A MRE11 MRE11 H2BC21 H2BC21 RAD50 RAD50 YWHAB YWHAB RAD17 RAD17 YWHAG YWHAG RFC2 RFC2 TOPBP1 TOPBP1 H2AX H2AX UBE2V2 UBE2V2 ATRIP ATRIP YWHAQ YWHAQ KAT5 KAT5 RFC3 RFC3 BRCC3 BRCC3 BARD1 BARD1 UBE2N UBE2N EXO1 EXO1 RPA2 RPA2 RNF168 RNF168
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFC5Replication factor C subunit 5. (343 aa)
LOC100152135Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC100152878Histone H2B; Belongs to the histone H2B family. (127 aa)
BLMBLM RecQ like helicase. (1432 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (260 aa)
NSD2Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa)
F1RWC9_PIGHistone domain-containing protein. (142 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (405 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (398 aa)
LOC100155267Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
RMI1RecQ mediated genome instability 1. (623 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
RFC4Replication factor C subunit 4. (364 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa)
WEE1Wee1-like protein kinase. (646 aa)
CDC25CM-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa)
WRNWRN RecQ like helicase. (1466 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4852 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
RMI2RecQ-mediated genome instability protein 2. (150 aa)
I3LAJ9_PIGHistone H2B; Belongs to the histone H2B family. (168 aa)
HIST1H2BDHistone H2B; Belongs to the histone H2B family. (126 aa)
RPA3Replication protein A3. (121 aa)
CCNB1Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
LOC100621389Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa)
TP53BP1Tumor protein p53 binding protein 1. (1931 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X4. (553 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (149 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (289 aa)
PIAS4Protein inhibitor of activated STAT 4. (566 aa)
CDK1Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (978 aa)
DNA2DNA replication helicase/nuclease 2. (1084 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1032 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
RAD50Zinc-hook domain-containing protein. (1358 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (264 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (711 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
RFC2Replication factor C subunit 2 isoform 1. (352 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1583 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
UBE2V2UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa)
ATRIPATR interacting protein. (823 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (246 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (316 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
UBE2NUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (147 aa)
EXO1Exonuclease 1. (836 aa)
RPA2RPA_C domain-containing protein. (270 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (575 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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