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| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (486 aa) |
| | SUOX | Sulfite oxidase, mitochondrial isoform X1. (545 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | TPH2 | Tryptophan hydroxylase 2. (491 aa) |
| | HAL | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | HYKK | Hydroxylysine kinase. (376 aa) |
| | PSME1 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa) |
| | PSMB11 | Proteasome subunit beta. (291 aa) |
| | ARG2 | Arginase. (354 aa) |
| | ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase acylating, mitochondrial isoform 1. (534 aa) |
| | PSMC1 | 26S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa) |
| | ETHE1 | ETHE1 persulfide dioxygenase. (257 aa) |
| | IL4I1 | Amine oxidase. (578 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | RIMKLA | Ribosomal modification protein rimK like family member A. (392 aa) |
| | AMD1 | S-adenosylmethionine decarboxylase proenzyme. (334 aa) |
| | HDC | Histidine decarboxylase. (662 aa) |
| | SQOR | Sulfide:quinone oxidoreductase, mitochondrial. (450 aa) |
| | GATM | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). (423 aa) |
| | SERINC4 | Serine incorporator 4. (517 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (363 aa) |
| | TYRP1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase. (562 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1027 aa) |
| | CARNMT1 | Carnosine N-methyltransferase isoform 1. (495 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (376 aa) |
| | GRHPR | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa) |
| | PSMB7 | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa) |
| | DBH | Dopamine beta-hydroxylase. (610 aa) |
| | ALDH9A1 | 4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. (596 aa) |
| | TSTD1 | Thiosulfate sulfurtransferase like domain containing 1. (137 aa) |
| | PSMD4 | Proteasome 26S subunit, non-ATPase 4. (380 aa) |
| | TSHB | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa) |
| | PSMA5 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa) |
| | IDO1 | Uncharacterized protein. (429 aa) |
| | SMOX | Spermine oxidase. (585 aa) |
| | NMRAL1 | NmrA like redox sensor 1. (312 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (312 aa) |
| | DCT | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (519 aa) |
| | AUH | Methylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family. (338 aa) |
| | SDSL | Serine dehydratase like. (353 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa) |
| | PCBD1 | Pterin-4 alpha-carbinolamine dehydratase 1. (104 aa) |
| | MAT1A | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (407 aa) |
| | GLUD1 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). (558 aa) |
| | ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa) |
| | PYCR2 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (450 aa) |
| | SAT1 | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity). (96 aa) |
| | TMLHE | Trimethyllysine dioxygenase, mitochondrial isoform 1. (421 aa) |
| | BBOX1 | Gamma-butyrobetaine hydroxylase 1. (387 aa) |
| | OAZ1 | Uncharacterized protein. (225 aa) |
| | SERINC5 | Serine incorporator 5. (631 aa) |
| | CDO1 | Cysteine dioxygenase. (200 aa) |
| | SLC6A7 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (635 aa) |
| | NAALAD2 | N-acetylated alpha-linked acidic dipeptidase 2. (740 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (545 aa) |
| | PSMC2 | AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (467 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | SCLY | Selenocysteine lyase. (451 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (402 aa) |
| | OGDH | Oxoglutarate dehydrogenase. (1035 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (534 aa) |
| | PNMT | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline. (283 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (421 aa) |
| | SLC3A2 | Solute carrier family 3 member 2. (562 aa) |
| | LIPT2 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (225 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa) |
| | SLC36A4 | Proton-coupled amino acid transporter 4 isoform 1. (543 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (410 aa) |
| | PSMF1 | Uncharacterized protein. (351 aa) |
| | GAMT | Guanidinoacetate N-methyltransferase. (267 aa) |
| | AMT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa) |
| | DIO1 | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). (249 aa) |
| | IDO2 | Indoleamine 2,3-dioxygenase 2. (412 aa) |
| | NAGS | N-acetyltransferase domain-containing protein. (381 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (605 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa) |
| | SRM | Spermidine synthase; Belongs to the spermidine/spermine synthase family. (323 aa) |
| | AZIN1 | Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (446 aa) |
| | HAO1 | Hydroxyacid oxidase 1. (370 aa) |
| | TYR | Tyrosinase. (531 aa) |
| | SLC44A1 | Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (665 aa) |
| | ARG1 | Arginase-1. (337 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa) |
| | SMS | Spermine synthase isoform X1. (368 aa) |
| | DUOX1 | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1552 aa) |
| | BCKDHA | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (562 aa) |
| | AADAT | Aminoadipate aminotransferase. (522 aa) |
| | DMGDH | Dimethylglycine dehydrogenase. (866 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | CHDH | Choline dehydrogenase. (517 aa) |
| | LOC110256626 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa) |
| | PSPH | Phosphoserine phosphatase isoform X1. (225 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | RIDA | Reactive intermediate imine deaminase A homolog. (137 aa) |
| | CKMT2 | Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (443 aa) |
| | A0A286ZS34_PIG | Uncharacterized protein. (179 aa) |
| | SHMT1 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (646 aa) |
| | AGXT2 | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa) |
| | MPST | Mercaptopyruvate sulfurtransferase. (308 aa) |
| | SLC6A8 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (635 aa) |
| | PPM1K | Protein phosphatase, Mg2+/Mn2+ dependent 1K. (373 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa) |
| | OAZ2 | Ornithine decarboxylase antizyme 2. (187 aa) |
| | SERINC3 | Serine incorporator 3. (474 aa) |
| | DAO | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. (371 aa) |
| | NAT8L | N-acetyltransferase 8 like. (302 aa) |
| | TXN2 | Thioredoxin 2. (255 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (277 aa) |
| | PAOX | Amino_oxidase domain-containing protein. (512 aa) |
| | ASS1 | Argininosuccinate synthase 1. (428 aa) |
| | ECHS1 | Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa) |
| | NDUFAB1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa) |
| | PSMD7 | Proteasome 26S subunit, non-ATPase 7. (324 aa) |
| | AMDHD1 | Amidohydrolase domain containing 1. (389 aa) |
| | SLC25A2 | Mitochondrial ornithine transporter 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa) |
| | SLC5A5 | Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (642 aa) |
| | PSME4 | Proteasome activator complex subunit 4. (1843 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (611 aa) |
| | CGA | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (144 aa) |
| | SLC25A10 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (286 aa) |
| | PHYKPL | 5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (479 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (401 aa) |
| | ASRGL1 | Asparaginase and isoaspartyl peptidase 1. (321 aa) |
| | TH | Tyrosine hydroxylase. (596 aa) |
| | LOC110258194 | Uncharacterized protein. (345 aa) |
| | ALDH7A1 | Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa) |
| | SLC6A12 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa) |
| | OAZ3 | Ornithine decarboxylase antizyme 3. (186 aa) |
| | ACADSB | Acyl-CoA dehydrogenase short/branched chain. (432 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1425 aa) |
| | SARDH | Sarcosine dehydrogenase, mitochondrial. (918 aa) |
| | AANAT | Aralkylamine N-acetyltransferase. (275 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (351 aa) |
| | PRODH2 | Uncharacterized protein. (1017 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (737 aa) |
| | SLC25A21 | Solute carrier family 25 member 21; Belongs to the mitochondrial carrier (TC 2.A.29) family. (299 aa) |
| | ADO | 2-aminoethanethiol (Cysteamine) dioxygenase. (270 aa) |
| | FMO1 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. (554 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (555 aa) |
| | DIO3 | Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. (305 aa) |
| | GCSH | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa) |
| | ASPG | Asparaginase. (661 aa) |
| | CARNS1 | Carnosine synthase 1 isoform 1. (951 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (961 aa) |
| | SLC25A15 | Solute carrier family 25 member 15; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa) |
| | OAT | Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa) |
| | MCCC1 | Methylcrotonoyl-CoA carboxylase 1. (911 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa) |
| | GLS | Glutaminase. (669 aa) |
| | GOT2 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (442 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | TST | Sulfurtransferase. (350 aa) |
| | UROC1 | Urocanate hydratase 1. (698 aa) |
| | RIMKLB | Ribosomal modification protein rimK like family member B. (386 aa) |
| | SGSM2 | Small G protein signaling modulator 2. (1341 aa) |
| | PSMB10 | Proteasome subunit beta. (296 aa) |
| | PSMA7 | Proteasome subunit alpha type. (267 aa) |
| | SLC6A11 | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | SLC25A13 | Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (687 aa) |
| | PAH | Phenylalanine hydroxylase. (450 aa) |
| | GADL1 | Glutamate decarboxylase like 1. (552 aa) |
| | PSMA1 | Proteasome subunit alpha type. (269 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (547 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (422 aa) |
| | AGMAT | Agmatinase; Belongs to the arginase family. (363 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa) |
| | BCKDK | Protein-serine/threonine kinase. (453 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (547 aa) |
| | DBT | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (729 aa) |
| | PSMA2 | Proteasome endopeptidase complex. (243 aa) |
| | NQO1 | Flavodoxin_2 domain-containing protein. (277 aa) |
| | FAH | Fumarylacetoacetase. (480 aa) |
| | AZIN2 | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (459 aa) |
| | SDS | Serine dehydratase. (402 aa) |
| | SERINC1 | Serine incorporator 1. (453 aa) |
| | PSMC5 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa) |
| | PSMA4 | Proteasome subunit alpha type. (281 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | PSMA3 | Proteasome subunit alpha type. (275 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (385 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (419 aa) |
| | HGD | Homogentisate 1,2-dioxygenase. (453 aa) |
| | HIBADH | 3-hydroxyisobutyrate dehydrogenase. (377 aa) |
| | BCAT1 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (436 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa) |
| | BCKDHB | Branched chain keto acid dehydrogenase E1 subunit beta. (396 aa) |
| | PSMB6 | Uncharacterized protein. (334 aa) |
| | SLC25A12 | Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (694 aa) |
| | CKM | Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (380 aa) |
| | SERINC2 | Serine incorporator 2. (483 aa) |
| | ODC1 | Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (619 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa) |
| | CRYM | Crystallin mu. (321 aa) |
| | GSTZ1 | Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (247 aa) |
| | KYAT1 | Aminotran_1_2 domain-containing protein. (461 aa) |
| | IVD | Uncharacterized protein. (568 aa) |
| | SLC7A5 | Solute carrier family 7 member 5. (585 aa) |
