STRINGSTRING
PDHX PDHX PPARD PPARD SUCLG1 SUCLG1 ME3 ME3 OGDH OGDH GLO1 GLO1 SDHA SDHA ME2 ME2 L2HGDH L2HGDH LDHA LDHA PDPR PDPR PDK3 PDK3 FH FH VDAC1 VDAC1 PDP1 PDP1 FAHD1 FAHD1 CS CS D2HGDH D2HGDH PDK2 PDK2 LDHB-2 LDHB-2 PDHB PDHB ADHFE1 ADHFE1 HAGH HAGH PDK1 PDK1 PDK4 PDK4 PDP2 PDP2 RXRA RXRA DLAT DLAT GSTZ1 GSTZ1 SDHC SDHC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (498 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (393 aa)
ME3Malic enzyme. (604 aa)
OGDHOxoglutarate dehydrogenase. (1035 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (664 aa)
ME2Malic enzyme. (678 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (463 aa)
LDHAL-lactate dehydrogenase A chain. (443 aa)
PDPRPyruvate dehydrogenase phosphatase regulatory subunit. (879 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa)
VDAC1Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa)
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (565 aa)
FAHD1Fumarylacetoacetate hydrolase domain containing 1. (224 aa)
CSCitrate synthase, mitochondrial; Belongs to the citrate synthase family. (464 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (578 aa)
PDK2Protein-serine/threonine kinase. (437 aa)
LDHB-2L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
ADHFE1Fe-ADH domain-containing protein. (489 aa)
HAGHLactamase_B domain-containing protein. (609 aa)
PDK1Protein-serine/threonine kinase. (454 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
PDP2Pyruvate dehydrogenase acetyl-transferring-phosphatase 2, mitochondrial. (531 aa)
RXRARetinoid X receptor alpha. (701 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (667 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (247 aa)
SDHCSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the cytochrome b560 family. (176 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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