(9 nodes) Ketone body metabolism network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	AACS	Acetoacetyl-CoA synthetase. (795 aa)
	HMGCLL1	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (425 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
	ACSS3	Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1. (686 aa)
	HMGCS2	Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (508 aa)
	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (562 aa)
	BDH2	3-hydroxybutyrate dehydrogenase type 2 isoform X2. (245 aa)
	BDH1	D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (346 aa)
	HMGCL	3-hydroxy-3-methylglutaryl-CoA lyase. (373 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAT1	ENSSSCP00000010417	ENSSSCP00000025827	Acetoacetyl-CoA synthetase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.960
AACS	BDH1	ENSSSCP00000010417	ENSSSCP00000012603	Acetoacetyl-CoA synthetase.	D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.944
AACS	BDH2	ENSSSCP00000010417	ENSSSCP00000023473	Acetoacetyl-CoA synthetase.	3-hydroxybutyrate dehydrogenase type 2 isoform X2.	0.932
AACS	HMGCL	ENSSSCP00000010417	ENSSSCP00000023921	Acetoacetyl-CoA synthetase.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.623
AACS	HMGCLL1	ENSSSCP00000010417	ENSSSCP00000001608	Acetoacetyl-CoA synthetase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.948
AACS	HMGCS2	ENSSSCP00000010417	ENSSSCP00000034427	Acetoacetyl-CoA synthetase.	Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family.	0.952
AACS	OXCT1	ENSSSCP00000010417	ENSSSCP00000068644	Acetoacetyl-CoA synthetase.	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.923
ACAT1	AACS	ENSSSCP00000025827	ENSSSCP00000010417	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetoacetyl-CoA synthetase.	0.960
ACAT1	ACSS3	ENSSSCP00000025827	ENSSSCP00000031574	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1.	0.506
ACAT1	BDH1	ENSSSCP00000025827	ENSSSCP00000012603	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.761
ACAT1	BDH2	ENSSSCP00000025827	ENSSSCP00000023473	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxybutyrate dehydrogenase type 2 isoform X2.	0.564
ACAT1	HMGCL	ENSSSCP00000025827	ENSSSCP00000023921	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.668
ACAT1	HMGCLL1	ENSSSCP00000025827	ENSSSCP00000001608	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.950
ACAT1	HMGCS2	ENSSSCP00000025827	ENSSSCP00000034427	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family.	0.991
ACAT1	OXCT1	ENSSSCP00000025827	ENSSSCP00000068644	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.975
ACSS3	ACAT1	ENSSSCP00000031574	ENSSSCP00000025827	Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.506
ACSS3	HMGCL	ENSSSCP00000031574	ENSSSCP00000023921	Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1.	3-hydroxy-3-methylglutaryl-CoA lyase.	0.637
ACSS3	HMGCLL1	ENSSSCP00000031574	ENSSSCP00000001608	Acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1.	3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1.	0.419
BDH1	AACS	ENSSSCP00000012603	ENSSSCP00000010417	D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Acetoacetyl-CoA synthetase.	0.944
BDH1	ACAT1	ENSSSCP00000012603	ENSSSCP00000025827	D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.761