(16 nodes) Purine catabolism network (Sus scrofa)

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Your Input:
	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (343 aa)
	DNPH1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (182 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (301 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (365 aa)
	XDH	Xanthine dehydrogenase/oxidase. (1336 aa)
	LOC100516797	Uncharacterized protein. (633 aa)
	NUDT18	Nudix hydrolase 18; Belongs to the Nudix hydrolase family. (322 aa)
	NUDT15	Nudix hydrolase 15. (171 aa)
	NT5C	5', 3'-nucleotidase, cytosolic. (255 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	NUDT16	Nudix hydrolase 16. (211 aa)
	NUDT1	Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (277 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (570 aa)
	ITPA	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (221 aa)
	NUDT5	Nudix hydrolase 5; Belongs to the Nudix hydrolase family. (270 aa)
	GDA	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (446 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADPRM	NUDT5	ENSSSCP00000071781	ENSSSCP00000060047	ADP-ribose/CDP-alcohol diphosphatase, manganese dependent.	Nudix hydrolase 5; Belongs to the Nudix hydrolase family.	0.902
GDA	NT5E	ENSSSCP00000071627	ENSSSCP00000030955	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.808
GDA	PNP	ENSSSCP00000071627	ENSSSCP00000002333	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.987
GDA	XDH	ENSSSCP00000071627	ENSSSCP00000009088	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	Xanthine dehydrogenase/oxidase.	0.968
ITPA	LOC100516797	ENSSSCP00000054471	ENSSSCP00000009177	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Uncharacterized protein.	0.926
ITPA	NT5C	ENSSSCP00000054471	ENSSSCP00000026452	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	5', 3'-nucleotidase, cytosolic.	0.915
ITPA	NT5C1A	ENSSSCP00000054471	ENSSSCP00000003967	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	5'-nucleotidase, cytosolic IA.	0.918
ITPA	NT5C2	ENSSSCP00000054471	ENSSSCP00000053367	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	5'-nucleotidase, cytosolic II.	0.904
ITPA	NT5E	ENSSSCP00000054471	ENSSSCP00000030955	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.907
ITPA	NUDT15	ENSSSCP00000054471	ENSSSCP00000021382	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Nudix hydrolase 15.	0.572
ITPA	NUDT16	ENSSSCP00000054471	ENSSSCP00000046177	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Nudix hydrolase 16.	0.925
ITPA	NUDT18	ENSSSCP00000054471	ENSSSCP00000010262	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Nudix hydrolase 18; Belongs to the Nudix hydrolase family.	0.557
ITPA	NUDT5	ENSSSCP00000054471	ENSSSCP00000060047	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	Nudix hydrolase 5; Belongs to the Nudix hydrolase family.	0.547
LOC100516797	ITPA	ENSSSCP00000009177	ENSSSCP00000054471	Uncharacterized protein.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.926
LOC100516797	NT5C	ENSSSCP00000009177	ENSSSCP00000026452	Uncharacterized protein.	5', 3'-nucleotidase, cytosolic.	0.947
LOC100516797	NT5C1A	ENSSSCP00000009177	ENSSSCP00000003967	Uncharacterized protein.	5'-nucleotidase, cytosolic IA.	0.902
LOC100516797	NT5C2	ENSSSCP00000009177	ENSSSCP00000053367	Uncharacterized protein.	5'-nucleotidase, cytosolic II.	0.934
LOC100516797	NT5E	ENSSSCP00000009177	ENSSSCP00000030955	Uncharacterized protein.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.916
LOC100516797	NUDT16	ENSSSCP00000009177	ENSSSCP00000046177	Uncharacterized protein.	Nudix hydrolase 16.	0.900
LOC100516797	PNP	ENSSSCP00000009177	ENSSSCP00000002333	Uncharacterized protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.919