Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GRB10 | GRB2 | ENSSSCP00000031279 | ENSSSCP00000018229 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Growth factor receptor-bound protein 2 isoform 1. | 0.547 |
| GRB10 | INS | ENSSSCP00000031279 | ENSSSCP00000044635 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.792 |
| GRB10 | INSR | ENSSSCP00000031279 | ENSSSCP00000014414 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Tyrosine-protein kinase receptor. | 0.973 |
| GRB10 | IRS1 | ENSSSCP00000031279 | ENSSSCP00000061240 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Insulin receptor substrate 1. | 0.754 |
| GRB10 | IRS2 | ENSSSCP00000031279 | ENSSSCP00000052323 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | Insulin receptor substrate 2. | 0.579 |
| GRB10 | SHC1 | ENSSSCP00000031279 | ENSSSCP00000028571 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | SHC adaptor protein 1. | 0.498 |
| GRB2 | GRB10 | ENSSSCP00000018229 | ENSSSCP00000031279 | Growth factor receptor-bound protein 2 isoform 1. | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.547 |
| GRB2 | INS | ENSSSCP00000018229 | ENSSSCP00000044635 | Growth factor receptor-bound protein 2 isoform 1. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.743 |
| GRB2 | INSR | ENSSSCP00000018229 | ENSSSCP00000014414 | Growth factor receptor-bound protein 2 isoform 1. | Tyrosine-protein kinase receptor. | 0.940 |
| GRB2 | IRS1 | ENSSSCP00000018229 | ENSSSCP00000061240 | Growth factor receptor-bound protein 2 isoform 1. | Insulin receptor substrate 1. | 0.998 |
| GRB2 | IRS2 | ENSSSCP00000018229 | ENSSSCP00000052323 | Growth factor receptor-bound protein 2 isoform 1. | Insulin receptor substrate 2. | 0.978 |
| GRB2 | MAPK1 | ENSSSCP00000018229 | ENSSSCP00000073842 | Growth factor receptor-bound protein 2 isoform 1. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.657 |
| GRB2 | MAPK3 | ENSSSCP00000018229 | ENSSSCP00000057520 | Growth factor receptor-bound protein 2 isoform 1. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.585 |
| GRB2 | SHC1 | ENSSSCP00000018229 | ENSSSCP00000028571 | Growth factor receptor-bound protein 2 isoform 1. | SHC adaptor protein 1. | 0.994 |
| GRB2 | SOS1 | ENSSSCP00000018229 | ENSSSCP00000009045 | Growth factor receptor-bound protein 2 isoform 1. | SOS Ras/Rac guanine nucleotide exchange factor 1. | 0.999 |
| INS | GRB10 | ENSSSCP00000044635 | ENSSSCP00000031279 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.792 |
| INS | GRB2 | ENSSSCP00000044635 | ENSSSCP00000018229 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Growth factor receptor-bound protein 2 isoform 1. | 0.743 |
| INS | INSR | ENSSSCP00000044635 | ENSSSCP00000014414 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase receptor. | 0.998 |
| INS | IRS1 | ENSSSCP00000044635 | ENSSSCP00000061240 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin receptor substrate 1. | 0.986 |
| INS | IRS2 | ENSSSCP00000044635 | ENSSSCP00000052323 | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Insulin receptor substrate 2. | 0.978 |
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