STRINGSTRING
PDPK1 PDPK1 PDE3B PDE3B FGF5 FGF5 FGF6 FGF6 INS INS AKT2 AKT2 FGF23 FGF23 FGF19 FGF19 GAB2 GAB2 IRS2 IRS2 PIK3CB PIK3CB PIK3CA PIK3CA FRS2 FRS2 FGF2 FGF2 FGF22 FGF22 PIK3R4 PIK3R4 MAPK3 MAPK3 TRIB3 TRIB3 FGF9 FGF9 PIK3R2 PIK3R2 MAPK1 MAPK1 IRS1 IRS1 PTPN11 PTPN11 FGF8 FGF8 FGF20 FGF20 SOS1 SOS1 KL KL FGF17 FGF17 TLR9 TLR9 FGF4 FGF4 FGF3 FGF3 INSR INSR FGF10 FGF10 GRB2 GRB2 KLB KLB FGF16 FGF16 PIK3R1 PIK3R1 FGF18 FGF18 FLT3 FLT3 SHC1 SHC1 GAB1 GAB1 FGFR1 FGFR1 FGFR4 FGFR4 GRB10 GRB10 A0A286ZJU7_PIG A0A286ZJU7_PIG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
PDE3BPhosphodiesterase. (1117 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
GAB2GRB2 associated binding protein 2. (740 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
TRIB3Tribbles pseudokinase 3. (373 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
PIK3R2Uncharacterized protein. (772 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
KLKlotho. (1011 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
KLBKlotho beta. (1044 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
SHC1SHC adaptor protein 1. (583 aa)
GAB1GRB2 associated binding protein 1. (723 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
FGFR4Fibroblast growth factor receptor. (903 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
A0A286ZJU7_PIGUncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (235 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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