STRINGSTRING
LRRK2 LRRK2 CCNE1 CCNE1 ARHGAP35 ARHGAP35 KXD1 KXD1 ERBB4 ERBB4 STAT3 STAT3 ERBB2 ERBB2 ERBB3 ERBB3 KRAS KRAS CDK4 CDK4 ARAP1 ARAP1 KHDRBS1 KHDRBS1 ELMO2 ELMO2 KHDRBS3 KHDRBS3 GPNMB GPNMB NRG3 NRG3 CBL CBL CRK CRK PTK6 PTK6 KHDRBS2 KHDRBS2 BTC BTC PTPN1 PTPN1 DOCK1 DOCK1 SFPQ SFPQ DOK1 DOK1 NRG1 NRG1 CDKN1B CDKN1B SRMS SRMS RHOA RHOA NRAS NRAS STAP2 STAP2 RPS27A RPS27A BCAR1 BCAR1 HIF1A HIF1A HRAS HRAS SOCS3 SOCS3 CCND1 CCND1 HBEGF HBEGF RASA1 RASA1 RAC1 RAC1 UBC UBC PXN PXN EREG EREG NRG2 NRG2 EGFR EGFR CDK2 CDK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRK2Uncharacterized protein. (2501 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1458 aa)
KHDRBS1KH RNA binding domain containing, signal transduction associated 1. (443 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
KHDRBS3KH RNA binding domain containing, signal transduction associated 3. (352 aa)
GPNMBGlycoprotein nmb. (565 aa)
NRG3Neuregulin 3. (718 aa)
CBLCbl proto-oncogene. (914 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PTK6Tyrosine-protein kinase. (449 aa)
KHDRBS2KH RNA binding domain containing, signal transduction associated 2. (349 aa)
BTCEGF-like domain-containing protein. (342 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
SFPQSplicing factor, proline-and glutamine-rich isoform X1. (702 aa)
DOK1Docking protein 1 isoform a. (505 aa)
NRG1Neuregulin 1. (712 aa)
CDKN1Bp27Kip1. (198 aa)
SRMSTyrosine-protein kinase. (494 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
STAP2Signal transducing adaptor family member 2. (462 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
RAC1Rac family small GTPase 1. (186 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PXNUncharacterized protein. (1072 aa)
EREGEpiregulin. (168 aa)
NRG2Neuregulin 2. (858 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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