STRINGSTRING
PTPN11 PTPN11 PIK3CD PIK3CD PLCG1 PLCG1 DOK5 DOK5 SOS1 SOS1 GFRA2 GFRA2 DOK2 DOK2 RET RET PSPN PSPN GRB2 GRB2 PRKCA PRKCA GRB7 GRB7 PIK3R1 PIK3R1 SHC1 SHC1 GAB1 GAB1 SRC SRC GRB10 GRB10 RAP1GAP RAP1GAP DOK1 DOK1 DOK6 DOK6 GDNF GDNF MAPK7 MAPK7 SHANK3 SHANK3 GFRA1 GFRA1 GAB2 GAB2 DOK4 DOK4 IRS2 IRS2 ARTN ARTN GFRA4 GFRA4 PIK3CB PIK3CB PIK3CA PIK3CA FRS2 FRS2 LOC100511937 LOC100511937 NRTN NRTN PDLIM7 PDLIM7 SHC3 SHC3 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
DOK5IRS-type PTB domain-containing protein. (316 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
DOK2Uncharacterized protein. (410 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
PSPNPersephin. (153 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
GRB7Growth factor receptor bound protein 7. (569 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
SHC1SHC adaptor protein 1. (583 aa)
GAB1GRB2 associated binding protein 1. (723 aa)
SRCTyrosine-protein kinase. (559 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
RAP1GAPRAP1 GTPase activating protein. (754 aa)
DOK1Docking protein 1 isoform a. (505 aa)
DOK6Docking protein 6. (331 aa)
GDNFGlial cell line-derived neurotrophic factor isoform 1. (211 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (840 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1740 aa)
GFRA1GDNF family receptor alpha 1. (570 aa)
GAB2GRB2 associated binding protein 2. (740 aa)
DOK4Docking protein 4. (365 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
ARTNArtemin. (227 aa)
GFRA4Uncharacterized protein. (367 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FRS2Fibroblast growth factor receptor substrate 2. (550 aa)
LOC100511937Uncharacterized protein. (532 aa)
NRTNNeurturin. (197 aa)
PDLIM7PDZ and LIM domain 7. (515 aa)
SHC3SHC adaptor protein 3. (656 aa)
PIK3R2Uncharacterized protein. (772 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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