STRINGSTRING
GRK2 GRK2 M6PR M6PR COPS7A COPS7A SYT1 SYT1 AP2A1 AP2A1 NECAP2 NECAP2 IGF2R IGF2R REPS1 REPS1 COPS2 COPS2 SH3GL2 SH3GL2 AVP AVP AREG AREG COPS4 COPS4 SYT2 SYT2 SH3KBP1 SH3KBP1 SH3GL1 SH3GL1 FCHO1 FCHO1 KXD1 KXD1 SYT9 SYT9 PICALM PICALM COPS8 COPS8 GRB2 GRB2 CD4 CD4 AP2B1 AP2B1 DVL2 DVL2 SYT8 SYT8 VAMP8 VAMP8 IL7R IL7R CD3D CD3D TFRC TFRC REPS2 REPS2 AGTR1 AGTR1 SLC18A3 SLC18A3 VAMP4 VAMP4 ARRB1 ARRB1 TACR1 TACR1 CBL CBL STON2 STON2 COPS7B COPS7B AP2M1 AP2M1 SNAP91 SNAP91 UBQLN2 UBQLN2 EPN1 EPN1 BTC BTC WNT5A WNT5A CLTA CLTA GPS1 GPS1 COPS5 COPS5 COPS6 COPS6 DAB2 DAB2 NEDD8 NEDD8 APOB APOB CD3G CD3G FCHO2 FCHO2 UBQLN1 UBQLN1 RPS27A RPS27A SYT11 SYT11 STAM2 STAM2 EPS15L1 EPS15L1 EPN2 EPN2 CHRM2 CHRM2 CLTB CLTB TOR1A TOR1A A0A5G2QCF0_PIG A0A5G2QCF0_PIG FZD4 FZD4 COPS3 COPS3 HBEGF HBEGF ARRB2 ARRB2 EPS15 EPS15 HGS HGS ITSN2 ITSN2 SCARB2 SCARB2 UBC UBC NECAP1 NECAP1 ITSN1 ITSN1 GRK3 GRK3 SLC2A8 SLC2A8 CLTC CLTC LDLRAP1 LDLRAP1 EREG EREG EGFR EGFR SH3GL3 SH3GL3 STAM STAM AP2S1 AP2S1 AP2A2 AP2A2 VAMP3 VAMP3 VAMP2 VAMP2 KIAA0319 KIAA0319
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRK2G protein-coupled receptor kinase 2. (778 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (339 aa)
COPS7ACOP9 signalosome subunit 7A. (296 aa)
SYT1Synaptotagmin 1. (379 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
NECAP2Adaptin ear-binding coat-associated protein 2 isoform 1. (266 aa)
IGF2RInsulin-like growth factor II receptor. (2488 aa)
REPS1RALBP1 associated Eps domain containing 1. (795 aa)
COPS2COP9 signalosome subunit 2. (450 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
AVPVasopressin-neurophysin 2-copeptin. (217 aa)
AREGAmphiregulin long form. (247 aa)
COPS4COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] (406 aa)
SYT2Synaptotagmin 2. (417 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (724 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (405 aa)
FCHO1FCH domain only 1. (969 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
SYT9Synaptotagmin-9. (491 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (700 aa)
COPS8COP9 signalosome subunit 8. (212 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CD4CD4 molecule. (494 aa)
AP2B1AP complex subunit beta. (957 aa)
DVL2Dishevelled segment polarity protein 2. (794 aa)
SYT8Synaptotagmin 8. (381 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (143 aa)
IL7RFibronectin type-III domain-containing protein. (458 aa)
CD3DT-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
REPS2RalBP1-associated Eps domain-containing protein 2 isoform 1. (648 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa)
SLC18A3Solute carrier family 18 member A3. (528 aa)
VAMP4Vesicle associated membrane protein 4. (175 aa)
ARRB1Arrestin beta 1. (607 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
CBLCbl proto-oncogene. (914 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (955 aa)
COPS7BCOP9 signalosome subunit 7B. (280 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
SNAP91Synaptosome associated protein 91. (906 aa)
UBQLN2Ubiquilin 2. (576 aa)
EPN1Epsin 1. (576 aa)
BTCEGF-like domain-containing protein. (342 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa)
GPS1G protein pathway suppressor 1. (664 aa)
COPS5COP9 signalosome subunit 5. (409 aa)
COPS6COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (358 aa)
DAB2DAB adaptor protein 2. (769 aa)
NEDD8NEDD8 ubiquitin like modifier. (71 aa)
APOBApolipoprotein B-100. (4573 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa)
FCHO2F-BAR domain only protein 2 isoform X1. (809 aa)
UBQLN1Ubiquilin 1. (582 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
SYT11Synaptotagmin 11. (438 aa)
STAM2Signal transducing adaptor molecule 2. (517 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (944 aa)
EPN2Epsin 2. (704 aa)
CHRM2Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. (466 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
TOR1ATorsin. (333 aa)
A0A5G2QCF0_PIGUncharacterized protein. (396 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
COPS3COP9 signalosome subunit 3. (426 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
ARRB2Arrestin beta 2. (493 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (979 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa)
ITSN2Intersectin 2. (1695 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (480 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
NECAP1NECAP endocytosis associated 1. (274 aa)
ITSN1Intersectin 1. (1485 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (675 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1702 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (336 aa)
EREGEpiregulin. (168 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (512 aa)
STAMSignal transducing adaptor molecule. (521 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
AP2A2Adaptor related protein complex 2 subunit alpha 2. (1108 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (217 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (189 aa)
KIAA0319KIAA0319. (1074 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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