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| | STON2 | Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (955 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (339 aa) |
| | COPS7A | COP9 signalosome subunit 7A. (296 aa) |
| | SYT1 | Synaptotagmin 1. (379 aa) |
| | AP2A1 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa) |
| | NECAP2 | Adaptin ear-binding coat-associated protein 2 isoform 1. (266 aa) |
| | IGF2R | Insulin-like growth factor II receptor. (2488 aa) |
| | REPS1 | RALBP1 associated Eps domain containing 1. (795 aa) |
| | COPS2 | COP9 signalosome subunit 2. (450 aa) |
| | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1. (352 aa) |
| | FNBP1L | Formin binding protein 1 like. (609 aa) |
| | AVP | Vasopressin-neurophysin 2-copeptin. (217 aa) |
| | ARPC1A | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa) |
| | HIP1 | Huntingtin interacting protein 1. (990 aa) |
| | AREG | Amphiregulin long form. (247 aa) |
| | COPS4 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] (406 aa) |
| | HIP1R | Huntingtin-interacting protein 1-related protein isoform 1. (1068 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa) |
| | SYT2 | Synaptotagmin 2. (417 aa) |
| | SH3KBP1 | SH3 domain containing kinase binding protein 1. (724 aa) |
| | SH3GL1 | SH3 domain containing GRB2 like 1, endophilin A2. (405 aa) |
| | FCHO1 | FCH domain only 1. (969 aa) |
| | KXD1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa) |
| | SYT9 | Synaptotagmin-9. (491 aa) |
| | PICALM | Phosphatidylinositol binding clathrin assembly protein. (700 aa) |
| | ARPC5 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa) |
| | ACTR3 | Actin related protein 3; Belongs to the actin family. (422 aa) |
| | COPS8 | COP9 signalosome subunit 8. (212 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | AP2B1 | AP complex subunit beta. (957 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (794 aa) |
| | SYNJ2 | Synaptojanin 2. (1402 aa) |
| | AMPH | Uncharacterized protein. (678 aa) |
| | SYT8 | Synaptotagmin 8. (381 aa) |
| | DNM1 | Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa) |
| | VAMP8 | V-SNARE coiled-coil homology domain-containing protein. (143 aa) |
| | PIK3C2A | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa) |
| | GAK | Cyclin G associated kinase. (1233 aa) |
| | IL7R | Fibronectin type-III domain-containing protein. (458 aa) |
| | CD3D | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (171 aa) |
| | TFRC | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa) |
| | REPS2 | RalBP1-associated Eps domain-containing protein 2 isoform 1. (648 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | GAPVD1 | GTPase activating protein and VPS9 domains 1. (1491 aa) |
| | SLC18A3 | Solute carrier family 18 member A3. (528 aa) |
| | VAMP4 | Vesicle associated membrane protein 4. (175 aa) |
| | ARRB1 | Arrestin beta 1. (607 aa) |
| | SNX18 | Sorting nexin 18. (807 aa) |
| | TACR1 | Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (394 aa) |
| | CBL | Cbl proto-oncogene. (914 aa) |
| | COPS7B | COP9 signalosome subunit 7B. (280 aa) |
| | RAB5A | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa) |
| | AP2M1 | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa) |
| | DNAJC6 | DnaJ heat shock protein family (Hsp40) member C6. (973 aa) |
| | SNAP91 | Synaptosome associated protein 91. (906 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | UBQLN2 | Ubiquilin 2. (576 aa) |
| | HSPA8 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (680 aa) |
| | ARPC4 | Actin related protein 2/3 complex subunit 4. (231 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (404 aa) |
| | EPN1 | Epsin 1. (576 aa) |
| | SYNJ1 | Synaptojanin 1. (1576 aa) |
| | BTC | EGF-like domain-containing protein. (342 aa) |
| | ARPC2 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (273 aa) |
| | PACSIN2 | Protein kinase C and casein kinase substrate in neurons 2. (538 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | CLTA | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa) |
| | GPS1 | G protein pathway suppressor 1. (664 aa) |
| | DNM3 | Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (863 aa) |
| | COPS5 | COP9 signalosome subunit 5. (409 aa) |
| | ACTG1 | Actin gamma 1. (381 aa) |
| | COPS6 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (358 aa) |
| | DAB2 | DAB adaptor protein 2. (769 aa) |
| | NEDD8 | NEDD8 ubiquitin like modifier. (71 aa) |
| | APOB | Apolipoprotein B-100. (4573 aa) |
| | CD3G | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of [...] (176 aa) |
| | PACSIN1 | Protein kinase C and casein kinase substrate in neurons 1. (376 aa) |
| | FCHO2 | F-BAR domain only protein 2 isoform X1. (809 aa) |
| | PACSIN3 | Protein kinase C and casein kinase substrate in neurons 3. (501 aa) |
| | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa) |
| | BIN1 | Bridging integrator 1. (588 aa) |
| | UBQLN1 | Ubiquilin 1. (582 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (204 aa) |
| | SYT11 | Synaptotagmin 11. (438 aa) |
| | STAM2 | Signal transducing adaptor molecule 2. (517 aa) |
| | EPS15L1 | Epidermal growth factor receptor pathway substrate 15 like 1. (944 aa) |
| | DNM2 | Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (877 aa) |
| | EPN2 | Epsin 2. (704 aa) |
| | CHRM2 | Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. (466 aa) |
| | CLTB | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa) |
| | TOR1A | Torsin. (333 aa) |
| | A0A5G2QCF0_PIG | Uncharacterized protein. (396 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | COPS3 | COP9 signalosome subunit 3. (426 aa) |
| | HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) |
| | ARRB2 | Arrestin beta 2. (493 aa) |
| | EPS15 | Epidermal growth factor receptor pathway substrate 15. (979 aa) |
| | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa) |
| | WASL | WASP like actin nucleation promoting factor. (511 aa) |
| | ITSN2 | Intersectin 2. (1695 aa) |
| | SCARB2 | Scavenger receptor class B member 2; Belongs to the CD36 family. (480 aa) |
| | UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) |
| | NECAP1 | NECAP endocytosis associated 1. (274 aa) |
| | ITSN1 | Intersectin 1. (1485 aa) |
| | FNBP1 | Formin binding protein 1. (616 aa) |
| | GRK3 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (675 aa) |
| | SLC2A8 | Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa) |
| | CLTC | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1702 aa) |
| | LDLRAP1 | Low density lipoprotein receptor adaptor protein 1. (336 aa) |
| | EREG | Epiregulin. (168 aa) |
| | OCRL | OCRL inositol polyphosphate-5-phosphatase. (903 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | SH3GL3 | SH3 domain containing GRB2 like 3, endophilin A3. (512 aa) |
| | STAM | Signal transducing adaptor molecule. (521 aa) |
| | AP2S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa) |
| | SNX9 | Sorting nexin 9. (632 aa) |
| | AP2A2 | Adaptor related protein complex 2 subunit alpha 2. (1108 aa) |
| | VAMP3 | V-SNARE coiled-coil homology domain-containing protein. (217 aa) |
| | VAMP2 | V-SNARE coiled-coil homology domain-containing protein. (189 aa) |
| | KIAA0319 | KIAA0319. (1074 aa) |
| | RAB5C | Uncharacterized protein. (227 aa) |
| | GRK2 | G protein-coupled receptor kinase 2. (778 aa) |
