(19 nodes) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WWOX	WW domain containing oxidoreductase. (414 aa)
	TFAP2D	Transcription factor AP-2 delta. (452 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	TFAP2C	Transcription factor AP-2 gamma (Activating enhancer binding protein 2 gamma). (450 aa)
	CREBBP	CREB-binding protein isoform a. (2440 aa)
	KDM5B	Lysine-specific demethylase 5B isoform 2. (1547 aa)
	EP300	E1A binding protein p300. (2420 aa)
	KCTD1	BTB/POZ domain-containing protein KCTD1 isoform b. (866 aa)
	NPM1	Nucleophosmin isoform 1. (294 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
	TFAP2E	Transcription factor AP-2 epsilon. (434 aa)
	TFAP2B	Transcription factor AP-2 beta. (469 aa)
	LHB-2	Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (173 aa)
	ATAD2	ATPase family AAA domain containing 2. (1384 aa)
	CGA	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (144 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
	LOC102167213	Uncharacterized protein. (192 aa)
	DEK	DEK proto-oncogene. (383 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD2	ESR1	ENSSSCP00000046009	ENSSSCP00000030835	ATPase family AAA domain containing 2.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.927
CGA	LHB-2	ENSSSCP00000046920	ENSSSCP00000039170	Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.	Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.	0.977
CITED1	CREBBP	ENSSSCP00000057865	ENSSSCP00000008490	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	CREB-binding protein isoform a.	0.716
CITED1	EP300	ENSSSCP00000057865	ENSSSCP00000020812	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	E1A binding protein p300.	0.869
CITED1	ESR1	ENSSSCP00000057865	ENSSSCP00000030835	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.543
CITED1	TFAP2A	ENSSSCP00000057865	ENSSSCP00000053009	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Transcription factor AP-2 alpha.	0.541
CITED1	TFAP2B	ENSSSCP00000057865	ENSSSCP00000039103	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Transcription factor AP-2 beta.	0.734
CITED1	TFAP2C	ENSSSCP00000057865	ENSSSCP00000007991	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Transcription factor AP-2 gamma (Activating enhancer binding protein 2 gamma).	0.634
CITED1	TFAP2D	ENSSSCP00000057865	ENSSSCP00000001901	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Transcription factor AP-2 delta.	0.541
CITED1	TFAP2E	ENSSSCP00000057865	ENSSSCP00000038275	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	Transcription factor AP-2 epsilon.	0.541
CITED2	CREBBP	ENSSSCP00000004474	ENSSSCP00000008490	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	CREB-binding protein isoform a.	0.922
CITED2	EP300	ENSSSCP00000004474	ENSSSCP00000020812	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	E1A binding protein p300.	0.957
CITED2	TFAP2A	ENSSSCP00000004474	ENSSSCP00000053009	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 alpha.	0.723
CITED2	TFAP2B	ENSSSCP00000004474	ENSSSCP00000039103	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 beta.	0.627
CITED2	TFAP2C	ENSSSCP00000004474	ENSSSCP00000007991	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 gamma (Activating enhancer binding protein 2 gamma).	0.649
CITED2	TFAP2D	ENSSSCP00000004474	ENSSSCP00000001901	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 delta.	0.567
CITED2	TFAP2E	ENSSSCP00000004474	ENSSSCP00000038275	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Transcription factor AP-2 epsilon.	0.627
CREBBP	CITED1	ENSSSCP00000008490	ENSSSCP00000057865	CREB-binding protein isoform a.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	0.716
CREBBP	CITED2	ENSSSCP00000008490	ENSSSCP00000004474	CREB-binding protein isoform a.	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	0.922
CREBBP	EP300	ENSSSCP00000008490	ENSSSCP00000020812	CREB-binding protein isoform a.	E1A binding protein p300.	0.997