STRINGSTRING
DOCK7 DOCK7 RAPGEF1 RAPGEF1 CRKL CRKL HGF HGF MET MET TNS3 TNS3 GRB2 GRB2 TNS4 TNS4 GAB1 GAB1 SRC SRC CRK CRK RAP1B RAP1B RAP1A RAP1A RAC1 RAC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2312 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1093 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
TNS3Tensin 3. (1563 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
TNS4Tensin-4. (716 aa)
GAB1GRB2 associated binding protein 1. (723 aa)
SRCTyrosine-protein kinase. (559 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAC1Rac family small GTPase 1. (186 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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