STRINGSTRING
PSME3 PSME3 PSMB9 PSMB9 PSME1 PSME1 PSMC1 PSMC1 SMAD4 SMAD4 PSMB7 PSMB7 PSMD4 PSMD4 PSMA5 PSMA5 PSMD6 PSMD6 KXD1 KXD1 PSMC2 PSMC2 PSMD1 PSMD1 SKP2 SKP2 PSMD3 PSMD3 PSMD11 PSMD11 CDK4 CDK4 CCNB1 CCNB1 PSMF1 PSMF1 PPM1D PPM1D PSMD9 PSMD9 SMAD1 SMAD1 CUL1 CUL1 PSMB3 PSMB3 A0A286ZS34_PIG A0A286ZS34_PIG PSMD12 PSMD12 PSMD7 PSMD7 CDK1 CDK1 SKP1 SKP1 RPS27A RPS27A RBM14 RBM14 PSMC4 PSMC4 RBX1 RBX1 PSMD8 PSMD8 PSMC6 PSMC6 STUB1 STUB1 PSMD14 PSMD14 PSMB1 PSMB1 PSMB10 PSMB10 PSMA7 PSMA7 CCND1 CCND1 PSMD10 PSMD10 PSMA1 PSMA1 PSMD5 PSMD5 UBC UBC PSMA2 PSMA2 PSMC5 PSMC5 PSMA4 PSMA4 PSMB2 PSMB2 PSMA3 PSMA3 PSMD13 PSMD13 PSMC3 PSMC3 PSMB6 PSMB6 RUNX2 RUNX2 CBFB CBFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
PSMB7Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (450 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
SKP2S-phase kinase-associated protein 2 isoform 1. (436 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
CCNB1Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
PSMF1Uncharacterized protein. (351 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (604 aa)
PSMD9PDZ domain-containing protein. (223 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CUL1Cullin 1; Belongs to the cullin family. (802 aa)
PSMB3Proteasome subunit beta. (205 aa)
A0A286ZS34_PIGUncharacterized protein. (179 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
CDK1Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
RBM14RNA-binding protein 14 isoform 1. (669 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB10Proteasome subunit beta. (296 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
PSMA4Proteasome subunit alpha type. (281 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (419 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMB6Uncharacterized protein. (334 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
CBFBCore-binding factor subunit beta. (204 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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