STRINGSTRING
KMT2C KMT2C SIN3A SIN3A RUNX1 RUNX1 KMT2A KMT2A H2AJ H2AJ PRMT6 PRMT6 H2BU1 H2BU1 ZFPM1 ZFPM1 H2AC6 H2AC6 HIST1H3E HIST1H3E LOC100620620 LOC100620620 H2BC21 H2BC21 PRMT1 PRMT1 H2AX H2AX H2AZ2 H2AZ2 WDR5 WDR5 LOC100152135 LOC100152135 LOC100152878 LOC100152878 KMT2B KMT2B CBFB CBFB H2AC20 H2AC20 LOC102159655 LOC102159655 SETD1A SETD1A H2AFZ H2AFZ LOC100155267 LOC100155267 SIN3B SIN3B RBBP5 RBBP5 LOC100521680 LOC100521680 ASH2L ASH2L EP300 EP300 I3LAJ9_PIG I3LAJ9_PIG HDAC1 HDAC1 GATA1 GATA1 HIST1H2BD HIST1H2BD KMT2E KMT2E LOC100158121 LOC100158121 KAT2B KAT2B LOC100621389 LOC100621389 A0A286ZRB3_PIG A0A286ZRB3_PIG H2BC11 H2BC11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KMT2CLysine methyltransferase 2C. (4977 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4000 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
PRMT6Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
ZFPM1Zinc finger protein, FOG family member 1. (965 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (145 aa)
HIST1H3EHistone H3; Belongs to the histone H3 family. (136 aa)
LOC100620620Histone H2A; Belongs to the histone H2A family. (113 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (383 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (145 aa)
WDR5WD repeat domain 5. (389 aa)
LOC100152135Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC100152878Histone H2B; Belongs to the histone H2B family. (127 aa)
KMT2BLysine methyltransferase 2B. (2595 aa)
CBFBCore-binding factor subunit beta. (204 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC102159655Histone H2A; Belongs to the histone H2A family. (130 aa)
SETD1ASET domain containing 1A, histone lysine methyltransferase. (1703 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
LOC100155267Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
SIN3BPaired amphipathic helix protein Sin3b isoform X1. (1121 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (517 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (635 aa)
EP300E1A binding protein p300. (2420 aa)
I3LAJ9_PIGHistone H2B; Belongs to the histone H2B family. (168 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
GATA1Erythroid transcription factor. (412 aa)
HIST1H2BDHistone H2B; Belongs to the histone H2B family. (126 aa)
KMT2EMyeloid/lymphoid or mixed-lineage leukemia 5. (1859 aa)
LOC100158121Histone H2A; Belongs to the histone H2A family. (130 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (831 aa)
LOC100621389Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
A0A286ZRB3_PIGHistone domain-containing protein. (130 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (149 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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