node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBFB | CCND1 | ENSSSCP00000071431 | ENSSSCP00000059262 | Core-binding factor subunit beta. | Cyclin D1; Belongs to the cyclin family. | 0.499 |
CBFB | EP300 | ENSSSCP00000071431 | ENSSSCP00000020812 | Core-binding factor subunit beta. | E1A binding protein p300. | 0.583 |
CBFB | HDAC4 | ENSSSCP00000071431 | ENSSSCP00000074232 | Core-binding factor subunit beta. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.499 |
CBFB | RUNX3 | ENSSSCP00000071431 | ENSSSCP00000065933 | Core-binding factor subunit beta. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.976 |
CBFB | TGFB1 | ENSSSCP00000071431 | ENSSSCP00000030317 | Core-binding factor subunit beta. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.408 |
CCND1 | CBFB | ENSSSCP00000059262 | ENSSSCP00000071431 | Cyclin D1; Belongs to the cyclin family. | Core-binding factor subunit beta. | 0.499 |
CCND1 | EP300 | ENSSSCP00000059262 | ENSSSCP00000020812 | Cyclin D1; Belongs to the cyclin family. | E1A binding protein p300. | 0.792 |
CCND1 | HDAC4 | ENSSSCP00000059262 | ENSSSCP00000074232 | Cyclin D1; Belongs to the cyclin family. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.783 |
CCND1 | RUNX3 | ENSSSCP00000059262 | ENSSSCP00000065933 | Cyclin D1; Belongs to the cyclin family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.614 |
CCND1 | TGFB1 | ENSSSCP00000059262 | ENSSSCP00000030317 | Cyclin D1; Belongs to the cyclin family. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.573 |
EP300 | CBFB | ENSSSCP00000020812 | ENSSSCP00000071431 | E1A binding protein p300. | Core-binding factor subunit beta. | 0.583 |
EP300 | CCND1 | ENSSSCP00000020812 | ENSSSCP00000059262 | E1A binding protein p300. | Cyclin D1; Belongs to the cyclin family. | 0.792 |
EP300 | HDAC4 | ENSSSCP00000020812 | ENSSSCP00000074232 | E1A binding protein p300. | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | 0.642 |
EP300 | RUNX3 | ENSSSCP00000020812 | ENSSSCP00000065933 | E1A binding protein p300. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.653 |
EP300 | TGFB1 | ENSSSCP00000020812 | ENSSSCP00000030317 | E1A binding protein p300. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.531 |
HDAC4 | CBFB | ENSSSCP00000074232 | ENSSSCP00000071431 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | Core-binding factor subunit beta. | 0.499 |
HDAC4 | CCND1 | ENSSSCP00000074232 | ENSSSCP00000059262 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | Cyclin D1; Belongs to the cyclin family. | 0.783 |
HDAC4 | EP300 | ENSSSCP00000074232 | ENSSSCP00000020812 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | E1A binding protein p300. | 0.642 |
HDAC4 | RUNX3 | ENSSSCP00000074232 | ENSSSCP00000065933 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.611 |
RUNX3 | CBFB | ENSSSCP00000065933 | ENSSSCP00000071431 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | Core-binding factor subunit beta. | 0.976 |