(20 nodes) Nucleotide salvage network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

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	HPRT1	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (224 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (849 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (301 aa)
	APRT	Pribosyltran domain-containing protein. (244 aa)
	ADAL	Adenosine deaminase-like protein isoform X1. (355 aa)
	UCK1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa)
	DGUOK	Deoxyguanosine kinase, mitochondrial isoform X1. (277 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	UPP2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (344 aa)
	PUDP	Pseudouridine-5'-phosphatase isoform b. (231 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (410 aa)
	AMPD3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (802 aa)
	GMPR2	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (352 aa)
	GMPR	IMPDH domain-containing protein. (485 aa)
	TK2	Thymidine kinase 2. (318 aa)
	TK1	Thymidine kinase. (229 aa)
	AMPD1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (750 aa)
	ADK	Adenosine kinase. (362 aa)
	ADA	Adenosine deaminase. (409 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	ADK	ENSSSCP00000070139	ENSSSCP00000067681	Adenosine deaminase.	Adenosine kinase.	0.992
ADA	AMPD1	ENSSSCP00000070139	ENSSSCP00000056286	Adenosine deaminase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.782
ADA	AMPD2	ENSSSCP00000070139	ENSSSCP00000044798	Adenosine deaminase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.818
ADA	AMPD3	ENSSSCP00000070139	ENSSSCP00000038421	Adenosine deaminase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.835
ADA	APRT	ENSSSCP00000070139	ENSSSCP00000002862	Adenosine deaminase.	Pribosyltran domain-containing protein.	0.893
ADA	CDA	ENSSSCP00000070139	ENSSSCP00000021047	Adenosine deaminase.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.680
ADA	GMPR	ENSSSCP00000070139	ENSSSCP00000048929	Adenosine deaminase.	IMPDH domain-containing protein.	0.573
ADA	GMPR2	ENSSSCP00000070139	ENSSSCP00000038930	Adenosine deaminase.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.573
ADA	HPRT1	ENSSSCP00000070139	ENSSSCP00000041929	Adenosine deaminase.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.539
ADA	PNP	ENSSSCP00000070139	ENSSSCP00000002333	Adenosine deaminase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.985
ADA	UPP1	ENSSSCP00000070139	ENSSSCP00000037244	Adenosine deaminase.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.439
ADA	UPP2	ENSSSCP00000070139	ENSSSCP00000026634	Adenosine deaminase.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.460
ADAL	ADK	ENSSSCP00000005076	ENSSSCP00000067681	Adenosine deaminase-like protein isoform X1.	Adenosine kinase.	0.558
ADAL	APRT	ENSSSCP00000005076	ENSSSCP00000002862	Adenosine deaminase-like protein isoform X1.	Pribosyltran domain-containing protein.	0.753
ADAL	HPRT1	ENSSSCP00000005076	ENSSSCP00000041929	Adenosine deaminase-like protein isoform X1.	Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	0.456
ADAL	PNP	ENSSSCP00000005076	ENSSSCP00000002333	Adenosine deaminase-like protein isoform X1.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.535
ADK	ADA	ENSSSCP00000067681	ENSSSCP00000070139	Adenosine kinase.	Adenosine deaminase.	0.992
ADK	ADAL	ENSSSCP00000067681	ENSSSCP00000005076	Adenosine kinase.	Adenosine deaminase-like protein isoform X1.	0.558
ADK	AMPD1	ENSSSCP00000067681	ENSSSCP00000056286	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.973
ADK	AMPD2	ENSSSCP00000067681	ENSSSCP00000044798	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.814