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| | SLC25A17 | Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (329 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (160 aa) |
| | LTA4H | Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (606 aa) |
| | ECI2 | Enoyl-CoA delta isomerase 2. (415 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | ACSBG1 | Acyl-CoA synthetase bubblegum family member 1. (709 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa) |
| | CYP1A1 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (538 aa) |
| | GPX2 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa) |
| | ACOT6 | Uncharacterized protein. (421 aa) |
| | CYP4A24 | Cytochrome P450 4A24; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Has no activity toward taurochenodeoxycholic acid; Belongs to the cytochrome P450 family. (482 aa) |
| | ACAA2 | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa) |
| | SLC27A2 | Solute carrier family 27 (Fatty acid transporter) member 2. (620 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | PTGES2 | Prostaglandin E synthase 2. (372 aa) |
| | PTGES | Microsomal prostaglandin E synthase-1. (153 aa) |
| | THEM5 | Acyl-coenzyme A thioesterase THEM5. (247 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) |
| | HADHB | Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (511 aa) |
| | HADHA | Trifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] (763 aa) |
| | MMAA | Methylmalonic aciduria type A protein, mitochondrial isoform X1. (420 aa) |
| | HPGDS | Hematopoietic prostaglandin D synthase. (199 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (332 aa) |
| | ACAD10 | Acyl-CoA dehydrogenase family member 10. (1036 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | HSD17B3 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (310 aa) |
| | ACAA1 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa) |
| | SLC25A20 | Mitochondrial carnitine/acylcarnitine carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa) |
| | ACAD11 | Acyl-CoA dehydrogenase family member 11. (780 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (732 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa) |
| | FADS2 | Cytochrome b5 heme-binding domain-containing protein. (712 aa) |
| | FADS1 | Cytochrome b5 heme-binding domain-containing protein. (481 aa) |
| | PON2 | Serum paraoxonase/arylesterase 2 isoform 1. (354 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (361 aa) |
| | ACADL | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa) |
| | TBXAS1 | Thromboxane-A synthase; Belongs to the cytochrome P450 family. (535 aa) |
| | ACLY | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1130 aa) |
| | ACSF2 | Acyl-CoA synthetase family member 2. (626 aa) |
| | ALOX15B | Arachidonate 15-lipoxygenase type B. (718 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (698 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (710 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa) |
| | PECR | Peroxisomal trans-2-enoyl-CoA reductase. (303 aa) |
| | ACOT8 | Acyl-coenzyme A thioesterase 8. (317 aa) |
| | DPEP3 | Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (555 aa) |
| | MID1IP1 | Mid1-interacting protein 1. (182 aa) |
| | ACSL5 | Acyl-CoA synthetase long chain family member 5. (705 aa) |
| | LTC4S | Leukotriene C4 synthase. (146 aa) |
| | CYP4F22 | Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa) |
| | EHHADH | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa) |
| | HSD17B12 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (325 aa) |
| | PPT2 | Palmitoyl-protein thioesterase 2. (309 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (786 aa) |
| | MCAT | Malonyl-CoA-acyl carrier protein transacylase. (483 aa) |
| | CYP2J34 | Uncharacterized protein; Belongs to the cytochrome P450 family. (554 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (638 aa) |
| | ACBD7 | Acyl-CoA binding domain containing 7. (88 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | MORC2 | MORC family CW-type zinc finger protein 2 isoform X2. (1038 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (288 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | MCEE | Methylmalonyl-CoA epimerase. (173 aa) |
| | ACSF3 | Acyl-CoA synthetase family member 3. (712 aa) |
| | PHYH | Phytanoyl-CoA 2-hydroxylase. (334 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) |
| | CYP2U1 | Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | CRAT | Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (745 aa) |
| | PON3 | Paraoxonase 3. (354 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa) |
| | EPHX2 | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators. The N- terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12- phosphonooxy-octadec-9Z-enoic acid and 12-phosphon [...] (575 aa) |
| | ECHS1 | Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (254 aa) |
| | NDUFAB1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1532 aa) |
| | TECRL | Trans-2,3-enoyl-CoA reductase-like. (363 aa) |
| | AKR1C1 | Aldo-keto reductase family 1 member C3 isoform 2. (324 aa) |
| | ACOX2 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (771 aa) |
| | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2. (674 aa) |
| | CYP4B1 | Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa) |
| | HACL1 | 2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (600 aa) |
| | PTGS1 | Prostaglandin G/H synthase 1 isoform 1. (600 aa) |
| | ACOXL | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (708 aa) |
| | GPX4 | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of s [...] (197 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) |
| | HTD2 | MaoC-like domain-containing protein. (180 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (347 aa) |
| | ACOT13 | Acyl-CoA thioesterase 13. (141 aa) |
| | PON1 | Paraoxonase 1. (355 aa) |
| | ACOT12 | Acyl-coenzyme A thioesterase 12 isoform X1. (559 aa) |
| | PPT1 | Palmitoyl-protein thioesterase 1. (305 aa) |
| | DBI | Acyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor; Belongs to the ACBP family. (88 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) |
| | FAAH | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. (579 aa) |
| | DPEP2 | Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (557 aa) |
| | PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domai [...] (730 aa) |
| | ACOT4 | Acyl-CoA thioesterase 4. (507 aa) |
| | CROT | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (612 aa) |
| | CBR1 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity). (289 aa) |
| | ACOT11 | Acyl-CoA thioesterase 11. (598 aa) |
| | ACSL3 | Acyl-CoA synthetase long chain family member 3. (729 aa) |
| | ALDH3A2 | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. (578 aa) |
| | HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (314 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | ACBD4 | Acyl-CoA binding domain containing 4. (317 aa) |
| | ACSL4 | Acyl-CoA synthetase long chain family member 4. (711 aa) |
| | ACSL6 | Long-chain-fatty-acid--CoA ligase 6 isoform X1. (722 aa) |
| | TECR | S5A_REDUCTASE domain-containing protein. (528 aa) |
| | CYP4F3 | Cytochrome P450 family 4 subfamily F member 3; Belongs to the cytochrome P450 family. (524 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (499 aa) |
| | PLA2G4A | Phospholipase A2. (758 aa) |
| | DECR2 | Peroxisomal 2,4-dienoyl-CoA reductase. (320 aa) |
| | HAO2 | Hydroxyacid oxidase 2 isoform 1. (353 aa) |
| | GGT5 | Gamma-glutamyltransferase 5. (639 aa) |
| | ACBD5 | Acyl-CoA binding domain containing 5. (596 aa) |
| | SLC25A1 | Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (539 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa) |
| | PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain [...] (558 aa) |
| | ACOT7 | Acyl-CoA thioesterase 7. (406 aa) |
| | CBR4 | Carbonyl reductase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa) |
| | ACOT9 | Acyl-CoA thioesterase 9. (449 aa) |
| | ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). (454 aa) |
| | ACADVL | Acyl-CoA dehydrogenase very long chain. (681 aa) |
| | THRSP | Uncharacterized protein. (156 aa) |
| | DECR1 | Uncharacterized protein. (348 aa) |
| | NUDT19 | Nudix hydrolase 19. (322 aa) |
| | CPT2 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa) |
| | ACBD6 | Acyl-CoA-binding domain-containing protein 6. (282 aa) |
| | RXRA | Retinoid X receptor alpha. (701 aa) |
| | SCD | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (425 aa) |
| | PCTP | START domain-containing protein. (234 aa) |
