STRINGSTRING
ARHGAP26 ARHGAP26 RACGAP1 RACGAP1 ARHGAP9 ARHGAP9 ARHGEF25 ARHGEF25 DEF6 DEF6 IQGAP1 IQGAP1 AKAP13 AKAP13 ARHGAP35 ARHGAP35 TAGAP TAGAP ARHGAP18 ARHGAP18 ARHGAP11A ARHGAP11A LMAN1 LMAN1 DAAM1 DAAM1 PKN3 PKN3 ARHGAP39 ARHGAP39 IQGAP3 IQGAP3 VANGL1 VANGL1 ARHGAP29 ARHGAP29 RHPN1 RHPN1 DLC1 DLC1 ARHGAP10 ARHGAP10 ARHGAP24 ARHGAP24 DIAPH3 DIAPH3 EMC3 EMC3 TIAM1 TIAM1 ARHGAP6 ARHGAP6 ARHGAP4 ARHGAP4 MYO9B MYO9B GMIP GMIP ARHGEF17 ARHGEF17 ARHGAP42 ARHGAP42 ANLN ANLN TRIO TRIO DOCK2 DOCK2 JUP JUP PLEKHG3 PLEKHG3 MACO1 MACO1 ARHGEF3 ARHGEF3 ARHGAP45 ARHGAP45 ARHGAP5 ARHGAP5 ARHGAP28 ARHGAP28 ARAP1 ARAP1 FAM13A FAM13A ARHGAP31 ARHGAP31 ARHGAP20 ARHGAP20 PIK3R1 PIK3R1 ARHGEF15 ARHGEF15 ARHGEF5 ARHGEF5 RHPN2 RHPN2 ARHGAP21 ARHGAP21 BCAP31 BCAP31 TFRC TFRC FLOT1 FLOT1 ECT2 ECT2 MCF2 MCF2 PKN2 PKN2 FAF2 FAF2 ARHGEF7 ARHGEF7 VAV1 VAV1 PREX2 PREX2 PREX1 PREX1 RASGRF2 RASGRF2 CAVIN1 CAVIN1 PLD1 PLD1 KTN1 KTN1 ARAP3 ARAP3 ARHGEF18 ARHGEF18 MYO9A MYO9A CCDC115 CCDC115 ATP6AP1 ATP6AP1 ARHGAP23 ARHGAP23 ARHGAP8 ARHGAP8 STARD8 STARD8 SNAP23 SNAP23 BCR BCR ARHGEF1 ARHGEF1 FLOT2 FLOT2 ABCD3 ABCD3 ARHGAP30 ARHGAP30 RHOA RHOA SLK SLK ARHGDIA ARHGDIA LBR LBR NGEF NGEF ARHGEF12 ARHGEF12 PKN1 PKN1 ARHGAP1 ARHGAP1 ARHGEF19 ARHGEF19 ARHGDIB ARHGDIB MCF2L MCF2L HMOX2 HMOX2 STOM STOM NET1 NET1 SRGAP1 SRGAP1 TJP2 TJP2 RTKN RTKN ARHGEF28 ARHGEF28 ARHGAP22 ARHGAP22 A0A287BGT3_PIG A0A287BGT3_PIG ARAP2 ARAP2 ARHGEF10L ARHGEF10L DDRGK1 DDRGK1 PLEKHG6 PLEKHG6 ACBD5 ACBD5 ARHGAP32 ARHGAP32 ABR ABR VAPB VAPB ROCK2 ROCK2 PIK3R2 PIK3R2 DEPDC1B DEPDC1B ROCK1 ROCK1 AAAS AAAS TMEM87A TMEM87A C1QBP C1QBP TEX2 TEX2 PLEKHG5 PLEKHG5 MCAM MCAM PCDH7 PCDH7 VAV3 VAV3 ARHGEF11 ARHGEF11 FARP1 FARP1 OPHN1 OPHN1 SCFD1 SCFD1 VAMP3 VAMP3 VAV2 VAV2 ARHGAP44 ARHGAP44 YKT6 YKT6 CIT CIT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGAP26Rho GTPase activating protein 26. (734 aa)
RACGAP1Rac GTPase activating protein 1. (634 aa)
ARHGAP9Rho GTPase activating protein 9. (808 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25 isoform X1. (590 aa)
DEF6Differentially expressed in FDCP 6 homolog. (631 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1709 aa)
AKAP13Uncharacterized protein. (1420 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
TAGAPRho-GAP domain-containing protein. (838 aa)
ARHGAP18Rho GTPase activating protein 18. (691 aa)
ARHGAP11ARho GTPase activating protein 11A. (1018 aa)
LMAN1Lectin, mannose binding 1. (518 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1086 aa)
PKN3Protein kinase N3. (861 aa)
ARHGAP39Rho GTPase activating protein 39. (1112 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1696 aa)
VANGL1Vang-like protein. (524 aa)
ARHGAP29Rho GTPase-activating protein 29 isoform a. (1260 aa)
RHPN1Rhophilin Rho GTPase binding protein 1. (659 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1528 aa)
ARHGAP10Rho GTPase-activating protein 10. (762 aa)
ARHGAP24Rho GTPase activating protein 24. (749 aa)
DIAPH3Diaphanous related formin 3. (1138 aa)
EMC3ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1611 aa)
ARHGAP6Rho GTPase activating protein 6. (705 aa)
ARHGAP4Rho GTPase activating protein 4. (979 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
GMIPGEM interacting protein. (1090 aa)
ARHGEF17DH domain-containing protein. (1043 aa)
ARHGAP42Rho GTPase activating protein 42. (871 aa)
ANLNAnillin actin binding protein. (1144 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3109 aa)
DOCK2Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1827 aa)
JUPJunction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
PLEKHG3Pleckstrin homology and RhoGEF domain containing G3. (1359 aa)
MACO1Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family. (664 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (569 aa)
ARHGAP45Rho GTPase activating protein 45. (1156 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
ARHGAP28Rho GTPase activating protein 28. (728 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1458 aa)
FAM13AFamily with sequence similarity 13 member A. (1020 aa)
ARHGAP31Rho GTPase-activating protein 31. (1453 aa)
ARHGAP20Rho GTPase activating protein 20. (1189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (844 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1574 aa)
RHPN2Rhophilin Rho GTPase binding protein 2. (686 aa)
ARHGAP21Rho GTPase activating protein 21. (1852 aa)
BCAP31B-cell receptor-associated protein 31 isoform b. (246 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
ECT2Epithelial cell transforming 2. (1028 aa)
MCF2MCF.2 cell line derived transforming sequence. (1172 aa)
PKN2Serine/threonine-protein kinase N2 isoform 1. (983 aa)
FAF2Fas associated factor family member 2. (445 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1614 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1270 aa)
CAVIN1Caveolae associated protein 1. (458 aa)
PLD1Phospholipase. (1074 aa)
KTN1Kinectin 1. (1358 aa)
ARAP3Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5. (1545 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X3. (1346 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2647 aa)
CCDC115Coiled-coil domain containing 115. (208 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (469 aa)
ARHGAP23Rho GTPase activating protein 23. (1145 aa)
ARHGAP8Uncharacterized protein. (486 aa)
STARD8StAR related lipid transfer domain containing 8. (1113 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
BCRBCR activator of RhoGEF and GTPase. (1274 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1181 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
ABCD3ATP binding cassette subfamily D member 3. (659 aa)
ARHGAP30Rho GTPase activating protein 30. (1071 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
SLKSTE20 like kinase. (1237 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (270 aa)
LBRLamin-B receptor. (626 aa)
NGEFNeuronal guanine nucleotide exchange factor. (823 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
PKN1Protein kinase N1. (956 aa)
ARHGAP1Rho GTPase activating protein 1. (450 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19 isoform X1. (879 aa)
ARHGDIBUncharacterized protein. (200 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1298 aa)
HMOX2Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (316 aa)
STOMStomatin. (267 aa)
NET1Neuroepithelial cell transforming 1. (574 aa)
SRGAP1SLIT-ROBO Rho GTPase-activating protein 1 isoform X1. (1085 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1187 aa)
RTKNRhotekin. (564 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1648 aa)
ARHGAP22Rho GTPase-activating protein 22 isoform X1. (722 aa)
A0A287BGT3_PIGRho-GAP domain-containing protein. (495 aa)
ARAP2ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2. (1735 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1274 aa)
DDRGK1DDRGK domain-containing protein 1. (312 aa)
PLEKHG6Pleckstrin homology domain-containing family G member 6 isoform X1. (791 aa)
ACBD5Acyl-CoA binding domain containing 5. (596 aa)
ARHGAP32Rho GTPase activating protein 32. (2089 aa)
ABRABR activator of RhoGEF and GTPase. (964 aa)
VAPBVesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (309 aa)
ROCK2Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
PIK3R2Uncharacterized protein. (772 aa)
DEPDC1BDEP domain containing 1B. (725 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
AAASAladin WD repeat nucleoporin. (554 aa)
TMEM87ATransmembrane protein 87A. (569 aa)
C1QBPMitochondrial complement component 1 Q subcomponent-binding protein. (281 aa)
TEX2Testis expressed 2. (1111 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
MCAMMelanoma cell adhesion molecule. (667 aa)
PCDH7Uncharacterized protein. (1246 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1577 aa)
FARP1FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1052 aa)
OPHN1Oligophrenin 1. (808 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (664 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (217 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
ARHGAP44Rho GTPase activating protein 44. (812 aa)
YKT6Uncharacterized protein; Belongs to the synaptobrevin family. (221 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2104 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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