(10 nodes) Interleukin-15 signaling network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAK3	Tyrosine-protein kinase. (1103 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
	IL2RG	Cytokine receptor common subunit gamma. (395 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	STAT3	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
	IL2RB	Fibronectin type-III domain-containing protein. (783 aa)
	IL15RA	Sushi domain-containing protein. (305 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB2	IL15RA	ENSSSCP00000018229	ENSSSCP00000025149	Growth factor receptor-bound protein 2 isoform 1.	Sushi domain-containing protein.	0.509
GRB2	IL2RB	ENSSSCP00000018229	ENSSSCP00000022046	Growth factor receptor-bound protein 2 isoform 1.	Fibronectin type-III domain-containing protein.	0.400
GRB2	IL2RG	ENSSSCP00000018229	ENSSSCP00000013192	Growth factor receptor-bound protein 2 isoform 1.	Cytokine receptor common subunit gamma.	0.400
GRB2	JAK1	ENSSSCP00000018229	ENSSSCP00000032415	Growth factor receptor-bound protein 2 isoform 1.	Tyrosine-protein kinase.	0.753
GRB2	JAK3	ENSSSCP00000018229	ENSSSCP00000030830	Growth factor receptor-bound protein 2 isoform 1.	Tyrosine-protein kinase.	0.665
GRB2	SHC1	ENSSSCP00000018229	ENSSSCP00000028571	Growth factor receptor-bound protein 2 isoform 1.	SHC adaptor protein 1.	0.994
GRB2	SOS1	ENSSSCP00000018229	ENSSSCP00000009045	Growth factor receptor-bound protein 2 isoform 1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
GRB2	SOS2	ENSSSCP00000018229	ENSSSCP00000005393	Growth factor receptor-bound protein 2 isoform 1.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.999
GRB2	STAT3	ENSSSCP00000018229	ENSSSCP00000018439	Growth factor receptor-bound protein 2 isoform 1.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.610
IL15RA	GRB2	ENSSSCP00000025149	ENSSSCP00000018229	Sushi domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.509
IL15RA	IL2RB	ENSSSCP00000025149	ENSSSCP00000022046	Sushi domain-containing protein.	Fibronectin type-III domain-containing protein.	0.800
IL15RA	IL2RG	ENSSSCP00000025149	ENSSSCP00000013192	Sushi domain-containing protein.	Cytokine receptor common subunit gamma.	0.800
IL15RA	JAK1	ENSSSCP00000025149	ENSSSCP00000032415	Sushi domain-containing protein.	Tyrosine-protein kinase.	0.683
IL15RA	JAK3	ENSSSCP00000025149	ENSSSCP00000030830	Sushi domain-containing protein.	Tyrosine-protein kinase.	0.694
IL15RA	SHC1	ENSSSCP00000025149	ENSSSCP00000028571	Sushi domain-containing protein.	SHC adaptor protein 1.	0.499
IL15RA	SOS1	ENSSSCP00000025149	ENSSSCP00000009045	Sushi domain-containing protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.499
IL15RA	SOS2	ENSSSCP00000025149	ENSSSCP00000005393	Sushi domain-containing protein.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.499
IL15RA	STAT3	ENSSSCP00000025149	ENSSSCP00000018439	Sushi domain-containing protein.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.537
IL2RB	GRB2	ENSSSCP00000022046	ENSSSCP00000018229	Fibronectin type-III domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.400
IL2RB	IL15RA	ENSSSCP00000022046	ENSSSCP00000025149	Fibronectin type-III domain-containing protein.	Sushi domain-containing protein.	0.800