(5 nodes) Interleukin-9 signaling network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAK1	Tyrosine-protein kinase. (1154 aa)
	STAT3	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
	IL9	Uncharacterized protein. (141 aa)
	JAK3	Tyrosine-protein kinase. (1103 aa)
	IL2RG	Cytokine receptor common subunit gamma. (395 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL2RG	IL9	ENSSSCP00000013192	ENSSSCP00000019202	Cytokine receptor common subunit gamma.	Uncharacterized protein.	0.900
IL2RG	JAK1	ENSSSCP00000013192	ENSSSCP00000032415	Cytokine receptor common subunit gamma.	Tyrosine-protein kinase.	0.905
IL2RG	JAK3	ENSSSCP00000013192	ENSSSCP00000030830	Cytokine receptor common subunit gamma.	Tyrosine-protein kinase.	0.905
IL2RG	STAT3	ENSSSCP00000013192	ENSSSCP00000018439	Cytokine receptor common subunit gamma.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.900
IL9	IL2RG	ENSSSCP00000019202	ENSSSCP00000013192	Uncharacterized protein.	Cytokine receptor common subunit gamma.	0.900
IL9	JAK1	ENSSSCP00000019202	ENSSSCP00000032415	Uncharacterized protein.	Tyrosine-protein kinase.	0.725
IL9	JAK3	ENSSSCP00000019202	ENSSSCP00000030830	Uncharacterized protein.	Tyrosine-protein kinase.	0.806
IL9	STAT3	ENSSSCP00000019202	ENSSSCP00000018439	Uncharacterized protein.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.707
JAK1	IL2RG	ENSSSCP00000032415	ENSSSCP00000013192	Tyrosine-protein kinase.	Cytokine receptor common subunit gamma.	0.905
JAK1	IL9	ENSSSCP00000032415	ENSSSCP00000019202	Tyrosine-protein kinase.	Uncharacterized protein.	0.725
JAK1	JAK3	ENSSSCP00000032415	ENSSSCP00000030830	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.960
JAK1	STAT3	ENSSSCP00000032415	ENSSSCP00000018439	Tyrosine-protein kinase.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.993
JAK3	IL2RG	ENSSSCP00000030830	ENSSSCP00000013192	Tyrosine-protein kinase.	Cytokine receptor common subunit gamma.	0.905
JAK3	IL9	ENSSSCP00000030830	ENSSSCP00000019202	Tyrosine-protein kinase.	Uncharacterized protein.	0.806
JAK3	JAK1	ENSSSCP00000030830	ENSSSCP00000032415	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.960
JAK3	STAT3	ENSSSCP00000030830	ENSSSCP00000018439	Tyrosine-protein kinase.	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	0.991
STAT3	IL2RG	ENSSSCP00000018439	ENSSSCP00000013192	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	Cytokine receptor common subunit gamma.	0.900
STAT3	IL9	ENSSSCP00000018439	ENSSSCP00000019202	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	Uncharacterized protein.	0.707
STAT3	JAK1	ENSSSCP00000018439	ENSSSCP00000032415	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	Tyrosine-protein kinase.	0.993
STAT3	JAK3	ENSSSCP00000018439	ENSSSCP00000030830	Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...]	Tyrosine-protein kinase.	0.991