STRINGSTRING
CIT CIT RTKN RTKN ARHGEF28 ARHGEF28 ARHGEF10L ARHGEF10L ARHGDIG ARHGDIG ARHGAP32 ARHGAP32 ABR ABR ROCK2 ROCK2 PIK3R2 PIK3R2 DEPDC1B DEPDC1B ROCK1 ROCK1 MCAM MCAM PCDH7 PCDH7 ARHGEF11 ARHGEF11 RHOB RHOB OPHN1 OPHN1 VAMP3 VAMP3 VAV2 VAV2 RACGAP1 RACGAP1 ARHGEF25 ARHGEF25 AKAP13 AKAP13 ARHGAP35 ARHGAP35 DAAM1 DAAM1 PKN3 PKN3 ARHGAP39 ARHGAP39 IQGAP3 IQGAP3 VANGL1 VANGL1 DLC1 DLC1 DIAPH3 DIAPH3 MYO9B MYO9B ARHGEF17 ARHGEF17 ANLN ANLN JUP JUP ARHGEF3 ARHGEF3 ARHGAP5 ARHGAP5 PIK3R1 PIK3R1 ARHGEF5 ARHGEF5 RHPN2 RHPN2 ARHGAP21 ARHGAP21 TFRC TFRC FLOT1 FLOT1 ECT2 ECT2 MCF2 MCF2 PKN2 PKN2 PREX1 PREX1 CAVIN1 CAVIN1 MYO9A MYO9A STARD8 STARD8 ARHGAP26 ARHGAP26 SNAP23 SNAP23 BCR BCR ARHGEF1 ARHGEF1 FLOT2 FLOT2 SLK SLK ARHGEF12 ARHGEF12 PKN1 PKN1 ARHGAP1 ARHGAP1 MCF2L MCF2L STOM STOM NET1 NET1 TJP2 TJP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2104 aa)
RTKNRhotekin. (564 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1648 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1274 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (267 aa)
ARHGAP32Rho GTPase activating protein 32. (2089 aa)
ABRABR activator of RhoGEF and GTPase. (964 aa)
ROCK2Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
PIK3R2Uncharacterized protein. (772 aa)
DEPDC1BDEP domain containing 1B. (725 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MCAMMelanoma cell adhesion molecule. (667 aa)
PCDH7Uncharacterized protein. (1246 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1577 aa)
RHOBRho-related GTP-binding protein RhoB. (196 aa)
OPHN1Oligophrenin 1. (808 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (217 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
RACGAP1Rac GTPase activating protein 1. (634 aa)
ARHGEF25Rho guanine nucleotide exchange factor 25 isoform X1. (590 aa)
AKAP13Uncharacterized protein. (1420 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1086 aa)
PKN3Protein kinase N3. (861 aa)
ARHGAP39Rho GTPase activating protein 39. (1112 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1696 aa)
VANGL1Vang-like protein. (524 aa)
DLC1Rho GTPase-activating protein 7 isoform X1. (1528 aa)
DIAPH3Diaphanous related formin 3. (1138 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
ARHGEF17DH domain-containing protein. (1043 aa)
ANLNAnillin actin binding protein. (1144 aa)
JUPJunction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (569 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1574 aa)
RHPN2Rhophilin Rho GTPase binding protein 2. (686 aa)
ARHGAP21Rho GTPase activating protein 21. (1852 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
ECT2Epithelial cell transforming 2. (1028 aa)
MCF2MCF.2 cell line derived transforming sequence. (1172 aa)
PKN2Serine/threonine-protein kinase N2 isoform 1. (983 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
CAVIN1Caveolae associated protein 1. (458 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2647 aa)
STARD8StAR related lipid transfer domain containing 8. (1113 aa)
ARHGAP26Rho GTPase activating protein 26. (734 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
BCRBCR activator of RhoGEF and GTPase. (1274 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1181 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
SLKSTE20 like kinase. (1237 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
PKN1Protein kinase N1. (956 aa)
ARHGAP1Rho GTPase activating protein 1. (450 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1298 aa)
STOMStomatin. (267 aa)
NET1Neuroepithelial cell transforming 1. (574 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1187 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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