(52 nodes) RHOQ GTPase cycle network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC42EP3	CDC42 effector protein 3. (254 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	SLC1A5	Amino acid transporter. (541 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1696 aa)
	VANGL1	Vang-like protein. (524 aa)
	DLC1	Rho GTPase-activating protein 7 isoform X1. (1528 aa)
	DIAPH3	Diaphanous related formin 3. (1138 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	CDC42EP2	Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
	SYDE1	Synapse defective Rho GTPase homolog 1. (735 aa)
	JUP	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
	GIT1	GIT ArfGAP 1. (761 aa)
	PLEKHG3	Pleckstrin homology and RhoGEF domain containing G3. (1359 aa)
	CPNE8	Copine-8. (577 aa)
	ARHGAP5	Rho GTPase-activating protein 5 isoform X1. (1503 aa)
	WWP2	E3 ubiquitin-protein ligase. (895 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1852 aa)
	TFRC	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	PAK1	Non-specific serine/threonine protein kinase. (546 aa)
	ARHGEF9	Uncharacterized protein. (1109 aa)
	RAB7A	RAB7A, member RAS oncogene family. (252 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	CDC42BPB	Serine/threonine-protein kinase MRCK beta isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1712 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
	CDC42BPA	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1847 aa)
	GIT2	GIT ArfGAP 2. (853 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ. (205 aa)
	GOPC	PDZ domain-containing protein. (463 aa)
	ARHGAP26	Rho GTPase activating protein 26. (734 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (601 aa)
	STEAP3	STEAP3 metalloreductase. (526 aa)
	ARHGAP1	Rho GTPase activating protein 1. (450 aa)
	STOM	Stomatin. (267 aa)
	GFOD1	Glucose-fructose oxidoreductase domain-containing protein 1 isoform 1. (390 aa)
	CDC42EP4	CDC42 effector protein 4. (357 aa)
	ARHGAP17	Rho GTPase activating protein 17. (930 aa)
	CDC42EP1	Cdc42 effector protein 1 isoform X1. (376 aa)
	SRGAP2	Uncharacterized protein. (1087 aa)
	ARHGAP32	Rho GTPase activating protein 32. (2089 aa)
	WASL	WASP like actin nucleation promoting factor. (511 aa)
	DEPDC1B	DEP domain containing 1B. (725 aa)
	SLC4A7	Anion exchange protein. (1254 aa)
	ITSN1	Intersectin 1. (1485 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa)
	FNBP1	Formin binding protein 1. (616 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (469 aa)
	ARHGAP33	Rho GTPase activating protein 33. (1310 aa)
	OPHN1	Oligophrenin 1. (808 aa)
	VAMP3	V-SNARE coiled-coil homology domain-containing protein. (217 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP1	ARHGAP33	ENSSSCP00000049547	ENSSSCP00000068596	Rho GTPase activating protein 1.	Rho GTPase activating protein 33.	0.465
ARHGAP1	ARHGEF7	ENSSSCP00000049547	ENSSSCP00000033427	Rho GTPase activating protein 1.	Rho guanine nucleotide exchange factor 7.	0.463
ARHGAP1	ARL13B	ENSSSCP00000049547	ENSSSCP00000066463	Rho GTPase activating protein 1.	ADP ribosylation factor like GTPase 13B.	0.400
ARHGAP1	CDC42	ENSSSCP00000049547	ENSSSCP00000029815	Rho GTPase activating protein 1.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.969
ARHGAP1	CDC42BPA	ENSSSCP00000049547	ENSSSCP00000036649	Rho GTPase activating protein 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.419
ARHGAP1	CDC42BPB	ENSSSCP00000049547	ENSSSCP00000035169	Rho GTPase activating protein 1.	Serine/threonine-protein kinase MRCK beta isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.419
ARHGAP1	CDC42EP1	ENSSSCP00000049547	ENSSSCP00000056762	Rho GTPase activating protein 1.	Cdc42 effector protein 1 isoform X1.	0.403
ARHGAP1	CDC42EP2	ENSSSCP00000049547	ENSSSCP00000013820	Rho GTPase activating protein 1.	Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family.	0.400
ARHGAP1	CDC42EP3	ENSSSCP00000049547	ENSSSCP00000072763	Rho GTPase activating protein 1.	CDC42 effector protein 3.	0.400
ARHGAP1	CDC42EP4	ENSSSCP00000049547	ENSSSCP00000052917	Rho GTPase activating protein 1.	CDC42 effector protein 4.	0.400
ARHGAP1	CPNE8	ENSSSCP00000049547	ENSSSCP00000021230	Rho GTPase activating protein 1.	Copine-8.	0.400
ARHGAP1	DEPDC1B	ENSSSCP00000049547	ENSSSCP00000062524	Rho GTPase activating protein 1.	DEP domain containing 1B.	0.400
ARHGAP1	DIAPH3	ENSSSCP00000049547	ENSSSCP00000010088	Rho GTPase activating protein 1.	Diaphanous related formin 3.	0.454
ARHGAP1	FNBP1	ENSSSCP00000049547	ENSSSCP00000063343	Rho GTPase activating protein 1.	Formin binding protein 1.	0.476
ARHGAP1	GFOD1	ENSSSCP00000049547	ENSSSCP00000052559	Rho GTPase activating protein 1.	Glucose-fructose oxidoreductase domain-containing protein 1 isoform 1.	0.400
ARHGAP1	GIT1	ENSSSCP00000049547	ENSSSCP00000018845	Rho GTPase activating protein 1.	GIT ArfGAP 1.	0.413
ARHGAP1	GIT2	ENSSSCP00000049547	ENSSSCP00000038248	Rho GTPase activating protein 1.	GIT ArfGAP 2.	0.403
ARHGAP1	IQGAP1	ENSSSCP00000049547	ENSSSCP00000001984	Rho GTPase activating protein 1.	IQ motif containing GTPase activating protein 1.	0.444
ARHGAP1	IQGAP3	ENSSSCP00000049547	ENSSSCP00000006900	Rho GTPase activating protein 1.	IQ motif containing GTPase activating protein 3.	0.694
ARHGAP1	JUP	ENSSSCP00000049547	ENSSSCP00000018469	Rho GTPase activating protein 1.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.487