32 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFRC	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
	PAK1	Non-specific serine/threonine protein kinase. (546 aa)
	ZAP70	Tyrosine-protein kinase. (615 aa)
	FAM91A1	Family with sequence similarity 91 member A1. (1081 aa)
	RAB7A	RAB7A, member RAS oncogene family. (252 aa)
	NIPSNAP2	Nipsnap homolog 2. (322 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	LCK	Tyrosine-protein kinase. (520 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (270 aa)
	ARHGDIB	Uncharacterized protein. (200 aa)
	STOM	Stomatin. (267 aa)
	TUBA1A	Detyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	UACA	Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1566 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (267 aa)
	ROCK2	Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa)
	SLC4A7	Anion exchange protein. (1254 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (729 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	WDR11	WD repeat domain 11. (1223 aa)
	PAK5	Non-specific serine/threonine protein kinase. (744 aa)
	TMEM59	Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. (343 aa)
	VAMP3	V-SNARE coiled-coil homology domain-containing protein. (217 aa)
	CSK	Tyrosine-protein kinase. (474 aa)
	SLC1A5	Amino acid transporter. (541 aa)
	PAK6	Non-specific serine/threonine protein kinase. (709 aa)
	VANGL1	Vang-like protein. (524 aa)
	NSFL1C	NSFL1 cofactor. (370 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	JUP	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa)
	OSBPL11	Oxysterol-binding protein; Belongs to the OSBP family. (774 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGDIA	ARHGDIB	ENSSSCP00000046156	ENSSSCP00000049666	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.903
ARHGDIA	ARHGDIG	ENSSSCP00000046156	ENSSSCP00000058157	Rho GDP dissociation inhibitor alpha.	Rho GDP dissociation inhibitor gamma.	0.433
ARHGDIA	RHOH	ENSSSCP00000046156	ENSSSCP00000038839	Rho GDP dissociation inhibitor alpha.	Rho-related GTP-binding protein RhoH.	0.712
ARHGDIB	ARHGDIA	ENSSSCP00000049666	ENSSSCP00000046156	Uncharacterized protein.	Rho GDP dissociation inhibitor alpha.	0.903
ARHGDIB	ARHGDIG	ENSSSCP00000049666	ENSSSCP00000058157	Uncharacterized protein.	Rho GDP dissociation inhibitor gamma.	0.420
ARHGDIB	RHOH	ENSSSCP00000049666	ENSSSCP00000038839	Uncharacterized protein.	Rho-related GTP-binding protein RhoH.	0.768
ARHGDIG	ARHGDIA	ENSSSCP00000058157	ENSSSCP00000046156	Rho GDP dissociation inhibitor gamma.	Rho GDP dissociation inhibitor alpha.	0.433
ARHGDIG	ARHGDIB	ENSSSCP00000058157	ENSSSCP00000049666	Rho GDP dissociation inhibitor gamma.	Uncharacterized protein.	0.420
ARHGDIG	RHOH	ENSSSCP00000058157	ENSSSCP00000038839	Rho GDP dissociation inhibitor gamma.	Rho-related GTP-binding protein RhoH.	0.704
CSK	DBT	ENSSSCP00000002078	ENSSSCP00000063492	Tyrosine-protein kinase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.411
CSK	FAM91A1	ENSSSCP00000002078	ENSSSCP00000032614	Tyrosine-protein kinase.	Family with sequence similarity 91 member A1.	0.400
CSK	JUP	ENSSSCP00000002078	ENSSSCP00000018469	Tyrosine-protein kinase.	Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...]	0.495
CSK	LAMTOR1	ENSSSCP00000002078	ENSSSCP00000073191	Tyrosine-protein kinase.	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.400
CSK	LCK	ENSSSCP00000002078	ENSSSCP00000043318	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.726
CSK	MTR	ENSSSCP00000002078	ENSSSCP00000010817	Tyrosine-protein kinase.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.400
CSK	NIPSNAP2	ENSSSCP00000002078	ENSSSCP00000034936	Tyrosine-protein kinase.	Nipsnap homolog 2.	0.434
CSK	NSFL1C	ENSSSCP00000002078	ENSSSCP00000007652	Tyrosine-protein kinase.	NSFL1 cofactor.	0.414
CSK	OSBPL11	ENSSSCP00000002078	ENSSSCP00000021355	Tyrosine-protein kinase.	Oxysterol-binding protein; Belongs to the OSBP family.	0.411
CSK	PAK1	ENSSSCP00000002078	ENSSSCP00000030505	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.452
CSK	PAK2	ENSSSCP00000002078	ENSSSCP00000012614	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.452