(64 nodes) RHOG GTPase cycle network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RHOG	Uncharacterized protein. (394 aa)
	DOCK4	Dedicator of cytokinesis 4; Belongs to the DOCK family. (1977 aa)
	ARHGDIG	Rho GDP dissociation inhibitor gamma. (267 aa)
	ARHGAP32	Rho GTPase activating protein 32. (2089 aa)
	VAPB	Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (309 aa)
	DEPDC1B	DEP domain containing 1B. (725 aa)
	ITSN1	Intersectin 1. (1485 aa)
	MCAM	Melanoma cell adhesion molecule. (667 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (874 aa)
	OPHN1	Oligophrenin 1. (808 aa)
	EMD	LEM domain-containing protein. (400 aa)
	ESYT1	Extended synaptotagmin 1. (1109 aa)
	VAMP3	V-SNARE coiled-coil homology domain-containing protein. (217 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (879 aa)
	YKT6	Uncharacterized protein; Belongs to the synaptobrevin family. (221 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa)
	NDUFA5	NADH:ubiquinone oxidoreductase subunit A5. (117 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	EPHA2	Ephrin type-A receptor 2 isoform 1. (975 aa)
	LMAN1	Lectin, mannose binding 1. (518 aa)
	ARHGAP39	Rho GTPase activating protein 39. (1112 aa)
	VANGL1	Vang-like protein. (524 aa)
	LETM1	Leucine zipper and EF-hand containing transmembrane protein 1. (791 aa)
	DIAPH3	Diaphanous related formin 3. (1138 aa)
	DOCK5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	HSPE1	Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3109 aa)
	DOCK2	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1827 aa)
	PLEKHG3	Pleckstrin homology and RhoGEF domain containing G3. (1359 aa)
	ARHGAP5	Rho GTPase-activating protein 5 isoform X1. (1503 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5. (1574 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1852 aa)
	ELMO2	Engulfment and cell motility 2. (732 aa)
	IQGAP2	IQ motif containing GTPase activating protein 2. (1542 aa)
	ANKLE2	Ankyrin repeat and LEM domain containing 2. (966 aa)
	TFRC	Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	VRK2	Serine/threonine-protein kinase VRK2. (507 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (1172 aa)
	ARFGAP3	ADP ribosylation factor GTPase activating protein 3. (613 aa)
	NDUFS3	NADH dehydrogenase ubiquinone iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (264 aa)
	RAB7A	RAB7A, member RAS oncogene family. (252 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1615 aa)
	PLD1	Phospholipase. (1074 aa)
	KTN1	Kinectin 1. (1358 aa)
	DOCK1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1828 aa)
	KIAA0355	KIAA0355. (1074 aa)
	DOCK3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (2071 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (766 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (270 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (601 aa)
	LBR	Lamin-B receptor. (626 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (872 aa)
	DSG2	Desmoglein 2. (1127 aa)
	ARHGAP1	Rho GTPase activating protein 1. (450 aa)
	ARHGDIB	Uncharacterized protein. (200 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1298 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase. (858 aa)
	RBM39	RNA-binding protein 39 isoform a. (530 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (503 aa)
	CDC42EP1	Cdc42 effector protein 1 isoform X1. (376 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKLE2	DIAPH3	ENSSSCP00000028199	ENSSSCP00000010088	Ankyrin repeat and LEM domain containing 2.	Diaphanous related formin 3.	0.491
ANKLE2	EMD	ENSSSCP00000028199	ENSSSCP00000070492	Ankyrin repeat and LEM domain containing 2.	LEM domain-containing protein.	0.741
ANKLE2	RBM39	ENSSSCP00000028199	ENSSSCP00000053421	Ankyrin repeat and LEM domain containing 2.	RNA-binding protein 39 isoform a.	0.509
ANKLE2	RHOG	ENSSSCP00000028199	ENSSSCP00000051183	Ankyrin repeat and LEM domain containing 2.	Uncharacterized protein.	0.531
ANKLE2	VRK2	ENSSSCP00000028199	ENSSSCP00000031825	Ankyrin repeat and LEM domain containing 2.	Serine/threonine-protein kinase VRK2.	0.819
ARFGAP3	CDC42	ENSSSCP00000032176	ENSSSCP00000029815	ADP ribosylation factor GTPase activating protein 3.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.482
ARFGAP3	CDC42EP1	ENSSSCP00000032176	ENSSSCP00000056762	ADP ribosylation factor GTPase activating protein 3.	Cdc42 effector protein 1 isoform X1.	0.400
ARFGAP3	DEPDC1B	ENSSSCP00000032176	ENSSSCP00000062524	ADP ribosylation factor GTPase activating protein 3.	DEP domain containing 1B.	0.400
ARFGAP3	DIAPH3	ENSSSCP00000032176	ENSSSCP00000010088	ADP ribosylation factor GTPase activating protein 3.	Diaphanous related formin 3.	0.407
ARFGAP3	DOCK1	ENSSSCP00000032176	ENSSSCP00000038012	ADP ribosylation factor GTPase activating protein 3.	Dedicator of cytokinesis 1; Belongs to the DOCK family.	0.756
ARFGAP3	DOCK2	ENSSSCP00000032176	ENSSSCP00000018020	ADP ribosylation factor GTPase activating protein 3.	Dedicator of cytokinesis protein 2; Belongs to the DOCK family.	0.400
ARFGAP3	DOCK3	ENSSSCP00000032176	ENSSSCP00000044545	ADP ribosylation factor GTPase activating protein 3.	Dedicator of cytokinesis 3; Belongs to the DOCK family.	0.400
ARFGAP3	DOCK4	ENSSSCP00000032176	ENSSSCP00000056810	ADP ribosylation factor GTPase activating protein 3.	Dedicator of cytokinesis 4; Belongs to the DOCK family.	0.415
ARFGAP3	DOCK5	ENSSSCP00000032176	ENSSSCP00000010303	ADP ribosylation factor GTPase activating protein 3.	Dedicator of cytokinesis 5; Belongs to the DOCK family.	0.400
ARFGAP3	DSG2	ENSSSCP00000032176	ENSSSCP00000047363	ADP ribosylation factor GTPase activating protein 3.	Desmoglein 2.	0.400
ARFGAP3	ELMO2	ENSSSCP00000032176	ENSSSCP00000027586	ADP ribosylation factor GTPase activating protein 3.	Engulfment and cell motility 2.	0.400
ARFGAP3	EPHA2	ENSSSCP00000032176	ENSSSCP00000003769	ADP ribosylation factor GTPase activating protein 3.	Ephrin type-A receptor 2 isoform 1.	0.415
ARFGAP3	HSPE1	ENSSSCP00000032176	ENSSSCP00000017034	ADP ribosylation factor GTPase activating protein 3.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.400
ARFGAP3	IQGAP2	ENSSSCP00000032176	ENSSSCP00000028043	ADP ribosylation factor GTPase activating protein 3.	IQ motif containing GTPase activating protein 2.	0.400
ARFGAP3	KIAA0355	ENSSSCP00000032176	ENSSSCP00000039013	ADP ribosylation factor GTPase activating protein 3.	KIAA0355.	0.400