(36 nodes) RHOU GTPase cycle network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	STAM	Signal transducing adaptor molecule. (521 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	PEAK1	Pseudopodium enriched atypical kinase 1. (1748 aa)
	EPHA2	Ephrin type-A receptor 2 isoform 1. (975 aa)
	TXNL1	Thioredoxin like 1. (394 aa)
	VANGL1	Vang-like protein. (524 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform 1. (217 aa)
	GIT1	GIT ArfGAP 1. (761 aa)
	RHOU	Ras homolog family member U. (258 aa)
	WWP2	E3 ubiquitin-protein ligase. (895 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
	ARHGAP31	Rho GTPase-activating protein 31. (1453 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	PAK1	Non-specific serine/threonine protein kinase. (546 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2365 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	DST	Dystonin. (7797 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2390 aa)
	GIT2	GIT ArfGAP 2. (853 aa)
	USP9X	Putative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
	ARHGAP30	Rho GTPase activating protein 30. (1071 aa)
	STAM2	Signal transducing adaptor molecule 2. (517 aa)
	WDR6	WD repeat domain 6. (1120 aa)
	SRGAP2	Uncharacterized protein. (1087 aa)
	PIK3R2	Uncharacterized protein. (772 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa)
	ITSN2	Intersectin 2. (1695 aa)
	DEPDC1B	DEP domain containing 1B. (725 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1702 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (354 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP30	ARHGAP31	ENSSSCP00000045618	ENSSSCP00000023886	Rho GTPase activating protein 30.	Rho GTPase-activating protein 31.	0.403
ARHGAP30	ARHGEF6	ENSSSCP00000045618	ENSSSCP00000043202	Rho GTPase activating protein 30.	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.429
ARHGAP30	ARHGEF7	ENSSSCP00000045618	ENSSSCP00000033427	Rho GTPase activating protein 30.	Rho guanine nucleotide exchange factor 7.	0.429
ARHGAP30	CDC42	ENSSSCP00000045618	ENSSSCP00000029815	Rho GTPase activating protein 30.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.575
ARHGAP30	CLTC	ENSSSCP00000045618	ENSSSCP00000065629	Rho GTPase activating protein 30.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.408
ARHGAP30	DEPDC1B	ENSSSCP00000045618	ENSSSCP00000062524	Rho GTPase activating protein 30.	DEP domain containing 1B.	0.400
ARHGAP30	DLG5	ENSSSCP00000045618	ENSSSCP00000071454	Rho GTPase activating protein 30.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.419
ARHGAP30	DST	ENSSSCP00000045618	ENSSSCP00000033447	Rho GTPase activating protein 30.	Dystonin.	0.513
ARHGAP30	EPHA2	ENSSSCP00000045618	ENSSSCP00000003769	Rho GTPase activating protein 30.	Ephrin type-A receptor 2 isoform 1.	0.401
ARHGAP30	GIT1	ENSSSCP00000045618	ENSSSCP00000018845	Rho GTPase activating protein 30.	GIT ArfGAP 1.	0.445
ARHGAP30	GIT2	ENSSSCP00000045618	ENSSSCP00000038248	Rho GTPase activating protein 30.	GIT ArfGAP 2.	0.453
ARHGAP30	GRB2	ENSSSCP00000045618	ENSSSCP00000018229	Rho GTPase activating protein 30.	Growth factor receptor-bound protein 2 isoform 1.	0.480
ARHGAP30	HGS	ENSSSCP00000045618	ENSSSCP00000061150	Rho GTPase activating protein 30.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]	0.400
ARHGAP30	IQGAP1	ENSSSCP00000045618	ENSSSCP00000001984	Rho GTPase activating protein 30.	IQ motif containing GTPase activating protein 1.	0.594
ARHGAP30	ITSN2	ENSSSCP00000045618	ENSSSCP00000061222	Rho GTPase activating protein 30.	Intersectin 2.	0.561
ARHGAP30	NCK1	ENSSSCP00000045618	ENSSSCP00000025894	Rho GTPase activating protein 30.	Cytoplasmic protein.	0.425
ARHGAP30	NCK2	ENSSSCP00000045618	ENSSSCP00000042553	Rho GTPase activating protein 30.	Cytoplasmic protein.	0.444
ARHGAP30	PAK1	ENSSSCP00000045618	ENSSSCP00000030505	Rho GTPase activating protein 30.	Non-specific serine/threonine protein kinase.	0.405
ARHGAP30	PAK2	ENSSSCP00000045618	ENSSSCP00000012614	Rho GTPase activating protein 30.	Non-specific serine/threonine protein kinase.	0.405
ARHGAP30	PARD6A	ENSSSCP00000045618	ENSSSCP00000067234	Rho GTPase activating protein 30.	Par-6 family cell polarity regulator alpha.	0.400