(34 nodes) RHOV GTPase cycle network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	GIT1	GIT ArfGAP 1. (761 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (1709 aa)
	PEAK1	Pseudopodium enriched atypical kinase 1. (1748 aa)
	EPHA2	Ephrin type-A receptor 2 isoform 1. (975 aa)
	TXNL1	Thioredoxin like 1. (394 aa)
	RHOV	Uncharacterized protein. (236 aa)
	PAK6	Non-specific serine/threonine protein kinase. (709 aa)
	VANGL1	Vang-like protein. (524 aa)
	SH3RF1	E3 ubiquitin-protein ligase SH3RF1 isoform X1. (849 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	CDC42	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
	PAK1	Non-specific serine/threonine protein kinase. (546 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2365 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (862 aa)
	DST	Dystonin. (7797 aa)
	PARD6B	Uncharacterized protein. (401 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2390 aa)
	MYO9A	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2647 aa)
	GIT2	GIT ArfGAP 2. (853 aa)
	ZNF512B	Zinc finger protein 512B. (975 aa)
	TPM4	Tropomyosin alpha-4 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. (284 aa)
	USP9X	Putative ubiquitin carboxyl-terminal hydrolase FAF-X isoform X4; Belongs to the peptidase C19 family. (2554 aa)
	NCK2	Cytoplasmic protein. (376 aa)
	ARHGAP12	Rho GTPase activating protein 12. (880 aa)
	MAP3K11	Mitogen-activated protein kinase kinase kinase. (858 aa)
	CCP110	Centriolar coiled-coil protein of 110 kDa isoform X1. (1011 aa)
	WDR6	WD repeat domain 6. (1120 aa)
	WASL	WASP like actin nucleation promoting factor. (511 aa)
	DEPDC1B	DEP domain containing 1B. (725 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1702 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (354 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP12	ARHGEF7	ENSSSCP00000047715	ENSSSCP00000033427	Rho GTPase activating protein 12.	Rho guanine nucleotide exchange factor 7.	0.432
ARHGAP12	CCP110	ENSSSCP00000047715	ENSSSCP00000051193	Rho GTPase activating protein 12.	Centriolar coiled-coil protein of 110 kDa isoform X1.	0.400
ARHGAP12	CDC42	ENSSSCP00000047715	ENSSSCP00000029815	Rho GTPase activating protein 12.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.544
ARHGAP12	CLTC	ENSSSCP00000047715	ENSSSCP00000065629	Rho GTPase activating protein 12.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.421
ARHGAP12	DEPDC1B	ENSSSCP00000047715	ENSSSCP00000062524	Rho GTPase activating protein 12.	DEP domain containing 1B.	0.404
ARHGAP12	DLG5	ENSSSCP00000047715	ENSSSCP00000071454	Rho GTPase activating protein 12.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.422
ARHGAP12	DST	ENSSSCP00000047715	ENSSSCP00000033447	Rho GTPase activating protein 12.	Dystonin.	0.727
ARHGAP12	EPHA2	ENSSSCP00000047715	ENSSSCP00000003769	Rho GTPase activating protein 12.	Ephrin type-A receptor 2 isoform 1.	0.427
ARHGAP12	GIT1	ENSSSCP00000047715	ENSSSCP00000018845	Rho GTPase activating protein 12.	GIT ArfGAP 1.	0.408
ARHGAP12	GIT2	ENSSSCP00000047715	ENSSSCP00000038248	Rho GTPase activating protein 12.	GIT ArfGAP 2.	0.408
ARHGAP12	IQGAP1	ENSSSCP00000047715	ENSSSCP00000001984	Rho GTPase activating protein 12.	IQ motif containing GTPase activating protein 1.	0.468
ARHGAP12	MAP3K11	ENSSSCP00000047715	ENSSSCP00000050426	Rho GTPase activating protein 12.	Mitogen-activated protein kinase kinase kinase.	0.675
ARHGAP12	MYO9A	ENSSSCP00000047715	ENSSSCP00000038105	Rho GTPase activating protein 12.	Myosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.491
ARHGAP12	NCK1	ENSSSCP00000047715	ENSSSCP00000025894	Rho GTPase activating protein 12.	Cytoplasmic protein.	0.420
ARHGAP12	NCK2	ENSSSCP00000047715	ENSSSCP00000042553	Rho GTPase activating protein 12.	Cytoplasmic protein.	0.420
ARHGAP12	PAK1	ENSSSCP00000047715	ENSSSCP00000030505	Rho GTPase activating protein 12.	Non-specific serine/threonine protein kinase.	0.482
ARHGAP12	PAK2	ENSSSCP00000047715	ENSSSCP00000012614	Rho GTPase activating protein 12.	Non-specific serine/threonine protein kinase.	0.482
ARHGAP12	PAK6	ENSSSCP00000047715	ENSSSCP00000005152	Rho GTPase activating protein 12.	Non-specific serine/threonine protein kinase.	0.482
ARHGAP12	PARD6A	ENSSSCP00000047715	ENSSSCP00000067234	Rho GTPase activating protein 12.	Par-6 family cell polarity regulator alpha.	0.400
ARHGAP12	PARD6B	ENSSSCP00000047715	ENSSSCP00000036345	Rho GTPase activating protein 12.	Uncharacterized protein.	0.400