(7 nodes) Interleukin-2 signaling network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHC1	SHC adaptor protein 1. (583 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	IL2RG	Cytokine receptor common subunit gamma. (395 aa)
	IL2RB	Fibronectin type-III domain-containing protein. (783 aa)
	LCK	Tyrosine-protein kinase. (520 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	JAK3	Tyrosine-protein kinase. (1103 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL2RB	IL2RG	ENSSSCP00000022046	ENSSSCP00000013192	Fibronectin type-III domain-containing protein.	Cytokine receptor common subunit gamma.	0.921
IL2RB	JAK1	ENSSSCP00000022046	ENSSSCP00000032415	Fibronectin type-III domain-containing protein.	Tyrosine-protein kinase.	0.900
IL2RB	JAK3	ENSSSCP00000022046	ENSSSCP00000030830	Fibronectin type-III domain-containing protein.	Tyrosine-protein kinase.	0.900
IL2RB	LCK	ENSSSCP00000022046	ENSSSCP00000043318	Fibronectin type-III domain-containing protein.	Tyrosine-protein kinase.	0.400
IL2RB	SHC1	ENSSSCP00000022046	ENSSSCP00000028571	Fibronectin type-III domain-containing protein.	SHC adaptor protein 1.	0.400
IL2RG	IL2RB	ENSSSCP00000013192	ENSSSCP00000022046	Cytokine receptor common subunit gamma.	Fibronectin type-III domain-containing protein.	0.921
IL2RG	JAK1	ENSSSCP00000013192	ENSSSCP00000032415	Cytokine receptor common subunit gamma.	Tyrosine-protein kinase.	0.905
IL2RG	JAK3	ENSSSCP00000013192	ENSSSCP00000030830	Cytokine receptor common subunit gamma.	Tyrosine-protein kinase.	0.905
IL2RG	LCK	ENSSSCP00000013192	ENSSSCP00000043318	Cytokine receptor common subunit gamma.	Tyrosine-protein kinase.	0.423
IL2RG	SHC1	ENSSSCP00000013192	ENSSSCP00000028571	Cytokine receptor common subunit gamma.	SHC adaptor protein 1.	0.400
JAK1	IL2RB	ENSSSCP00000032415	ENSSSCP00000022046	Tyrosine-protein kinase.	Fibronectin type-III domain-containing protein.	0.900
JAK1	IL2RG	ENSSSCP00000032415	ENSSSCP00000013192	Tyrosine-protein kinase.	Cytokine receptor common subunit gamma.	0.905
JAK1	JAK3	ENSSSCP00000032415	ENSSSCP00000030830	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.960
JAK1	LCK	ENSSSCP00000032415	ENSSSCP00000043318	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.498
JAK1	SHC1	ENSSSCP00000032415	ENSSSCP00000028571	Tyrosine-protein kinase.	SHC adaptor protein 1.	0.649
JAK3	IL2RB	ENSSSCP00000030830	ENSSSCP00000022046	Tyrosine-protein kinase.	Fibronectin type-III domain-containing protein.	0.900
JAK3	IL2RG	ENSSSCP00000030830	ENSSSCP00000013192	Tyrosine-protein kinase.	Cytokine receptor common subunit gamma.	0.905
JAK3	JAK1	ENSSSCP00000030830	ENSSSCP00000032415	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.960
JAK3	LCK	ENSSSCP00000030830	ENSSSCP00000043318	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.552
JAK3	PTK2B	ENSSSCP00000030830	ENSSSCP00000010320	Tyrosine-protein kinase.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.928