STRINGSTRING
PIK3R2 PIK3R2 CSF2RA CSF2RA LOC100511937 LOC100511937 PIK3CA PIK3CA PIK3CB PIK3CB GAB2 GAB2 INPP5D INPP5D PTPN6 PTPN6 JAK1 JAK1 JAK3 JAK3 JAK2 JAK2 SHC1 SHC1 PIK3R1 PIK3R1 IL2RB IL2RB CSF2 CSF2 GRB2 GRB2 IL2RG IL2RG IL5RA IL5RA SOS1 SOS1 PIK3CD PIK3CD CSF2RB CSF2RB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R2Uncharacterized protein. (772 aa)
CSF2RAFibronectin type-III domain-containing protein. (446 aa)
LOC100511937Uncharacterized protein. (532 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
GAB2GRB2 associated binding protein 2. (740 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
SHC1SHC adaptor protein 1. (583 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
IL2RBFibronectin type-III domain-containing protein. (783 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (144 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
IL2RGCytokine receptor common subunit gamma. (395 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (893 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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