STRINGSTRING
CAMK2B CAMK2B IFNB1 IFNB1 PLCG1 PLCG1 PPM1B PPM1B OASL OASL PDE12 PDE12 EIF4A2 EIF4A2 EIF4G2 EIF4G2 CAMK2A CAMK2A EIF4E2 EIF4E2 EIF4A3 EIF4A3 KPNA1 KPNA1 HERC5 HERC5 SOCS1 SOCS1 EIF4A1 EIF4A1 UBE2L6 UBE2L6 EIF4E EIF4E IFNGR1 IFNGR1 IRF3 IRF3 JAK2 JAK2 IFNAR2 IFNAR2 JAK1 JAK1 TYK2 TYK2 IFNG IFNG PTPN6 PTPN6 EIF4E3 EIF4E3 PTPN1 PTPN1 ISG15 ISG15 EIF4G3 EIF4G3 IFN-ALPHA-15 IFN-ALPHA-15 UBA7 UBA7 USP18 USP18 SOCS3 SOCS3 EIF4G1 EIF4G1 IFNGR2 IFNGR2 CAMK2G CAMK2G IFN-ALPHA-8 IFN-ALPHA-8 RNASEL RNASEL PRKCD PRKCD LOC102160336 LOC102160336 MX2 MX2 NEDD4 NEDD4 FLNB FLNB EIF2AK2 EIF2AK2 LOC100737265 LOC100737265 MAPK3 MAPK3 PTPN2 PTPN2 IRF9 IRF9 IFN-ALPHA-9 IFN-ALPHA-9 IFNA1 IFNA1 PTPN11 PTPN11 A0A5G2QZT5_PIG A0A5G2QZT5_PIG TRIM25 TRIM25 STAT2 STAT2 KPNB1 KPNB1 PIAS1 PIAS1 UBE2N UBE2N ABCE1 ABCE1 CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (670 aa)
IFNB1Interferon-beta-1. (186 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
PPM1BPPM-type phosphatase domain-containing protein. (473 aa)
OASL2'-5'-oligoadenylate synthase-like protein isoform a. (348 aa)
PDE122',5'-phosphodiesterase 12 isoform 1. (609 aa)
EIF4A2Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (410 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (949 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1; Belongs to the protein kinase superfamily. (489 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
EIF4A3Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
KPNA1IBB domain-containing protein. (648 aa)
HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5. (968 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
EIF4A1Eukaryotic translation initiation factor 4A isoform 1; Belongs to the DEAD box helicase family. (406 aa)
UBE2L6UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa)
IFNGR1Interferon gamma receptor 1. (470 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
IFNAR2Uncharacterized protein. (574 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
TYK2Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
EIF4E3Eukaryotic translation initiation factor 4E family member 3; Belongs to the eukaryotic initiation factor 4E family. (266 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ISG15Ubiquitin-like modifier. (167 aa)
EIF4G3Eukaryotic translation initiation factor 4 gamma 3. (1658 aa)
IFN-ALPHA-15Uncharacterized protein. (225 aa)
UBA7Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
USP18USP domain-containing protein; Belongs to the peptidase C19 family. (376 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1613 aa)
IFNGR2Interferon gamma receptor 2 isoform 1. (369 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (595 aa)
IFN-ALPHA-8Uncharacterized protein. (226 aa)
RNASEL2-5A-dependent ribonuclease. (743 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
LOC102160336UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
MX2Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity against influenza virus A (FLUAV). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (711 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform 3. (1323 aa)
FLNBFilamin B. (2633 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
LOC100737265Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (447 aa)
IRF9IRF tryptophan pentad repeat domain-containing protein. (418 aa)
IFN-ALPHA-9Interferon-alpha-9. (189 aa)
IFNA1Uncharacterized protein. (189 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
A0A5G2QZT5_PIGUncharacterized protein. (178 aa)
TRIM25Tripartite motif containing 25. (633 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
KPNB1Karyopherin subunit beta 1. (877 aa)
PIAS1Protein inhibitor of activated STAT 1. (685 aa)
UBE2NUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (147 aa)
ABCE1ATP binding cassette subfamily E member 1. (589 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopath [...] (532 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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