STRINGSTRING
FLT3 FLT3 GRB10 GRB10 CBL CBL GRAP2 GRAP2 LCK LCK SOCS6 SOCS6 CDKN1B CDKN1B NRAS NRAS ABL2 ABL2 RPS27A RPS27A HRAS HRAS GAB2 GAB2 UBC UBC PIK3CA PIK3CA CSK CSK FOXO3 FOXO3 SOS1 SOS1 SH2B3 SH2B3 KXD1 KXD1 GRB2 GRB2 PTPRJ PTPRJ SLA SLA KRAS KRAS PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
CBLCbl proto-oncogene. (914 aa)
GRAP2GRB2-related adapter protein 2 isoform 1. (320 aa)
LCKTyrosine-protein kinase. (520 aa)
SOCS6Suppressor of cytokine signaling 6 isoform X1. (535 aa)
CDKN1Bp27Kip1. (198 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
ABL2Tyrosine-protein kinase. (1096 aa)
RPS27AUbiquitin-like domain-containing protein. (204 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GAB2GRB2 associated binding protein 2. (740 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CSKTyrosine-protein kinase. (474 aa)
FOXO3Forkhead box protein O3 isoform X1. (672 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
SH2B3SH2B adaptor protein 3. (600 aa)
KXD1Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (305 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1340 aa)
SLASH2 domain-containing protein. (403 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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