(37 nodes) RND3 GTPase cycle network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RBM39	RNA-binding protein 39 isoform a. (530 aa)
	WDR6	WD repeat domain 6. (1120 aa)
	KCTD13	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1. (329 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (771 aa)
	PIK3R2	Uncharacterized protein. (772 aa)
	DEPDC1B	DEP domain containing 1B. (725 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
	TMOD3	Uncharacterized protein. (386 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1920 aa)
	CKAP4	Uncharacterized protein. (591 aa)
	DSP	Desmoplakin. (2883 aa)
	FAM83B	Family with sequence similarity 83 member B. (1011 aa)
	ARHGAP35	Rho GTPase-activating protein 35. (1500 aa)
	EPHA2	Ephrin type-A receptor 2 isoform 1. (975 aa)
	TXNL1	Thioredoxin like 1. (394 aa)
	VANGL2	Vang-like protein. (521 aa)
	VANGL1	Vang-like protein. (524 aa)
	NISCH	Nischarin. (1520 aa)
	MUC13	Uncharacterized protein. (537 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (700 aa)
	CPD	Carboxypeptidase D. (1374 aa)
	DSG1	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). (1045 aa)
	ARHGAP5	Rho GTPase-activating protein 5 isoform X1. (1503 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
	TNFAIP1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2. (316 aa)
	PTPN13	Protein tyrosine phosphatase non-receptor type 13. (2491 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1852 aa)
	RBMX	RNA binding motif protein X-linked. (408 aa)
	RASAL2	RAS protein activator like 2. (1279 aa)
	DST	Dystonin. (7797 aa)
	KTN1	Kinectin 1. (1358 aa)
	YME1L1	ANK_REP_REGION domain-containing protein. (2031 aa)
	UBXN11	UBX domain protein 11. (514 aa)
	PKP4	Plakophilin 4. (1234 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	CCDC88A	Coiled-coil domain containing 88A. (1873 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP21	CCDC88A	ENSSSCP00000027534	ENSSSCP00000052178	Rho GTPase activating protein 21.	Coiled-coil domain containing 88A.	0.449
ARHGAP21	DSG1	ENSSSCP00000027534	ENSSSCP00000020931	Rho GTPase activating protein 21.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.401
ARHGAP21	WDR6	ENSSSCP00000027534	ENSSSCP00000058016	Rho GTPase activating protein 21.	WD repeat domain 6.	0.487
ARHGAP35	ARHGAP5	ENSSSCP00000003363	ENSSSCP00000021934	Rho GTPase-activating protein 35.	Rho GTPase-activating protein 5 isoform X1.	0.900
ARHGAP35	DSG1	ENSSSCP00000003363	ENSSSCP00000020931	Rho GTPase-activating protein 35.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.400
ARHGAP5	ARHGAP35	ENSSSCP00000021934	ENSSSCP00000003363	Rho GTPase-activating protein 5 isoform X1.	Rho GTPase-activating protein 35.	0.900
ARHGAP5	DSG1	ENSSSCP00000021934	ENSSSCP00000020931	Rho GTPase-activating protein 5 isoform X1.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.400
ARHGAP5	DST	ENSSSCP00000021934	ENSSSCP00000033447	Rho GTPase-activating protein 5 isoform X1.	Dystonin.	0.581
ARHGAP5	RASAL2	ENSSSCP00000021934	ENSSSCP00000032671	Rho GTPase-activating protein 5 isoform X1.	RAS protein activator like 2.	0.633
CCDC88A	ARHGAP21	ENSSSCP00000052178	ENSSSCP00000027534	Coiled-coil domain containing 88A.	Rho GTPase activating protein 21.	0.449
CCDC88A	DSG1	ENSSSCP00000052178	ENSSSCP00000020931	Coiled-coil domain containing 88A.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.405
CCDC88A	WDR6	ENSSSCP00000052178	ENSSSCP00000058016	Coiled-coil domain containing 88A.	WD repeat domain 6.	0.493
CKAP4	DSG1	ENSSSCP00000000178	ENSSSCP00000020931	Uncharacterized protein.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.400
CPD	DSG1	ENSSSCP00000018857	ENSSSCP00000020931	Carboxypeptidase D.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.402
CPD	PICALM	ENSSSCP00000018857	ENSSSCP00000015834	Carboxypeptidase D.	Phosphatidylinositol binding clathrin assembly protein.	0.423
DEPDC1B	DLG5	ENSSSCP00000062524	ENSSSCP00000071454	DEP domain containing 1B.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.423
DEPDC1B	DSG1	ENSSSCP00000062524	ENSSSCP00000020931	DEP domain containing 1B.	Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).	0.404
DEPDC1B	DST	ENSSSCP00000062524	ENSSSCP00000033447	DEP domain containing 1B.	Dystonin.	0.400
DEPDC1B	EPHA2	ENSSSCP00000062524	ENSSSCP00000003769	DEP domain containing 1B.	Ephrin type-A receptor 2 isoform 1.	0.428
DEPDC1B	FLOT2	ENSSSCP00000062524	ENSSSCP00000044809	DEP domain containing 1B.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.400