(20 nodes) Antigen Presentation: Folding, assembly and peptide loading of class I MHC network (Sus scrofa)

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Your Input:
	CALR	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa)
	ERAP2	Aminopeptidase. (951 aa)
	ERAP1	Aminopeptidase. (922 aa)
	BCAP31	B-cell receptor-associated protein 31 isoform b. (246 aa)
	K7GNK3_PIG	Ig-like domain-containing protein; Belongs to the MHC class I family. (349 aa)
	SAR1B	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). (198 aa)
	SEC24A	SEC24 homolog A, COPII coat complex component. (1133 aa)
	CANX	Calnexin. (615 aa)
	SLA-8	Ig-like domain-containing protein; Belongs to the MHC class I family. (434 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (157 aa)
	SEC31A	SEC31 homolog A, COPII coat complex component. (1251 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (341 aa)
	SLA-6	Ig-like domain-containing protein; Belongs to the MHC class I family. (462 aa)
	TAP2	Uncharacterized protein. (726 aa)
	TAP1	Transporter 1, ATP binding cassette subfamily B member. (718 aa)
	SEC23A	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
	PDIA3	Protein disulfide-isomerase. (504 aa)
	SEC24D	SEC24 homolog D, COPII coat complex component. (1033 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1258 aa)
	SEC24C	SEC24 homolog C, COPII coat complex component. (1118 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	CALR	ENSSSCP00000050390	ENSSSCP00000014615	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family.	0.926
B2M	CANX	ENSSSCP00000050390	ENSSSCP00000048577	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Calnexin.	0.418
B2M	K7GNK3_PIG	ENSSSCP00000050390	ENSSSCP00000029457	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.762
B2M	PDIA3	ENSSSCP00000050390	ENSSSCP00000005064	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Protein disulfide-isomerase.	0.935
B2M	SAR1B	ENSSSCP00000050390	ENSSSCP00000042292	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity).	0.542
B2M	SEC13	ENSSSCP00000050390	ENSSSCP00000073167	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.541
B2M	SEC23A	ENSSSCP00000050390	ENSSSCP00000002115	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.521
B2M	SEC24A	ENSSSCP00000050390	ENSSSCP00000048484	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	SEC24 homolog A, COPII coat complex component.	0.507
B2M	SEC24B	ENSSSCP00000050390	ENSSSCP00000009748	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	SEC24 homolog B, COPII coat complex component.	0.516
B2M	SEC24C	ENSSSCP00000050390	ENSSSCP00000010987	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	SEC24 homolog C, COPII coat complex component.	0.499
B2M	SEC24D	ENSSSCP00000050390	ENSSSCP00000009721	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	SEC24 homolog D, COPII coat complex component.	0.499
B2M	SEC31A	ENSSSCP00000050390	ENSSSCP00000067869	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	SEC31 homolog A, COPII coat complex component.	0.499
B2M	SLA-6	ENSSSCP00000050390	ENSSSCP00000001485	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.847
B2M	SLA-8	ENSSSCP00000050390	ENSSSCP00000049757	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Ig-like domain-containing protein; Belongs to the MHC class I family.	0.961
B2M	TAP1	ENSSSCP00000050390	ENSSSCP00000001588	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Transporter 1, ATP binding cassette subfamily B member.	0.689
B2M	TAP2	ENSSSCP00000050390	ENSSSCP00000001578	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).	Uncharacterized protein.	0.665
BCAP31	CALR	ENSSSCP00000029439	ENSSSCP00000014615	B-cell receptor-associated protein 31 isoform b.	Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family.	0.425
BCAP31	CANX	ENSSSCP00000029439	ENSSSCP00000048577	B-cell receptor-associated protein 31 isoform b.	Calnexin.	0.490
BCAP31	PDIA3	ENSSSCP00000029439	ENSSSCP00000005064	B-cell receptor-associated protein 31 isoform b.	Protein disulfide-isomerase.	0.452
BCAP31	SEC24C	ENSSSCP00000029439	ENSSSCP00000010987	B-cell receptor-associated protein 31 isoform b.	SEC24 homolog C, COPII coat complex component.	0.486