STRINGSTRING
PSME3 PSME3 PSMB9 PSMB9 NFKBIE NFKBIE NFKBIA NFKBIA PSME1 PSME1 PSMB11 PSMB11 PSMC1 PSMC1 PLCG2 PLCG2 PIK3CD PIK3CD PSMA8 PSMA8 RASGRP1 RASGRP1 PSMB7 PSMB7 LYN LYN PSMD4 PSMD4 PSMA5 PSMA5 BCL10 BCL10 FKBP1A FKBP1A REL REL SOS1 SOS1 F1S9H7_PIG F1S9H7_PIG LOC100523213 LOC100523213 CHUK CHUK PSMD6 PSMD6 SH3KBP1 SH3KBP1 RELA RELA PSMC2 PSMC2 PSMD1 PSMD1 GRB2 GRB2 CD79B CD79B PSMD3 PSMD3 PSMD11 PSMD11 I3LBK0_PIG I3LBK0_PIG KRAS KRAS PSMF1 PSMF1 PIK3R1 PIK3R1 NFKBIB NFKBIB F1STC2_PIG F1STC2_PIG BTK BTK NCK1 NCK1 A0A075B7H8_PIG A0A075B7H8_PIG MALT1 MALT1 PSMD9 PSMD9 PSMB3 PSMB3 A0A286ZP42_PIG A0A286ZP42_PIG A0A286ZQH2_PIG A0A286ZQH2_PIG VAV1 VAV1 A0A286ZS34_PIG A0A286ZS34_PIG A0A286ZRV9_PIG A0A286ZRV9_PIG A0A286ZTC9_PIG A0A286ZTC9_PIG PTPN6 PTPN6 PSMD12 PSMD12 DAPP1 DAPP1 CARD11 CARD11 A0A287A3T6_PIG A0A287A3T6_PIG LOC100623670 LOC100623670 A0A287A4Y3_PIG A0A287A4Y3_PIG CD19 CD19 A0A287A9X3_PIG A0A287A9X3_PIG PSMD7 PSMD7 A0A287AEB1_PIG A0A287AEB1_PIG CD22 CD22 A0A287AM45_PIG A0A287AM45_PIG PSME4 PSME4 NRAS NRAS A0A287AU93_PIG A0A287AU93_PIG NFKB1 NFKB1 IKBKG IKBKG HRAS HRAS PSMC4 PSMC4 PSMD8 PSMD8 RASGRP3 RASGRP3 A0A287BAB3_PIG A0A287BAB3_PIG STIM1 STIM1 PSMC6 PSMC6 A0A287BH28_PIG A0A287BH28_PIG A0A287BHK5_PIG A0A287BHK5_PIG ITPR3 ITPR3 A0A287BLH9_PIG A0A287BLH9_PIG PSMD14 PSMD14 PSMB1 PSMB1 TRPC1 TRPC1 LAC_PIG LAC_PIG A0A287BNX9_PIG A0A287BNX9_PIG A0A287BRE1_PIG A0A287BRE1_PIG PSMB10 PSMB10 PSMA7 PSMA7 PSMD10 PSMD10 CD79A CD79A A0A5G2Q8Z5_PIG A0A5G2Q8Z5_PIG PSMA1 PSMA1 PSMD5 PSMD5 PSMA2 PSMA2 BLNK BLNK ITPR1 ITPR1 PSMC5 PSMC5 PIK3AP1 PIK3AP1 PSMA4 PSMA4 PSMB2 PSMB2 PSMA3 PSMA3 PSMD13 PSMD13 PSMC3 PSMC3 PSMB6 PSMB6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (265 aa)
PSMB9Proteasome subunit beta. (219 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
PSME1Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (284 aa)
PSMB11Proteasome subunit beta. (291 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1201 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
PSMB7Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (277 aa)
LYNTyrosine-protein kinase. (512 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (380 aa)
PSMA5Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (232 aa)
BCL10B-cell lymphoma/leukemia 10 isoform 1. (233 aa)
FKBP1APeptidylprolyl isomerase. (240 aa)
RELREL proto-oncogene, NF-kB subunit. (586 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
F1S9H7_PIGIg-like domain-containing protein. (158 aa)
LOC100523213Ig-like domain-containing protein. (212 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (450 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (724 aa)
RELATranscription factor p65 isoform 1. (573 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CD79BCD79b molecule. (228 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (421 aa)
I3LBK0_PIGIg-like domain-containing protein. (218 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PSMF1Uncharacterized protein. (351 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (766 aa)
NFKBIBNFKB inhibitor beta. (361 aa)
F1STC2_PIGIg-like domain-containing protein. (216 aa)
BTKTyrosine-protein kinase. (659 aa)
NCK1Cytoplasmic protein. (377 aa)
A0A075B7H8_PIGIg-like domain-containing protein. (101 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
PSMD9PDZ domain-containing protein. (223 aa)
PSMB3Proteasome subunit beta. (205 aa)
A0A286ZP42_PIGIGv domain-containing protein. (147 aa)
A0A286ZQH2_PIGIg-like domain-containing protein. (111 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
A0A286ZS34_PIGUncharacterized protein. (179 aa)
A0A286ZRV9_PIGIg-like domain-containing protein. (192 aa)
A0A286ZTC9_PIGUncharacterized protein. (647 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (281 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
A0A287A3T6_PIGIg-like domain-containing protein. (156 aa)
LOC100623670Ig-like domain-containing protein. (315 aa)
A0A287A4Y3_PIGIg-like domain-containing protein. (226 aa)
CD19CD19 molecule. (645 aa)
A0A287A9X3_PIGIGv domain-containing protein. (120 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
A0A287AEB1_PIGIg-like domain-containing protein. (106 aa)
CD22CD22 molecule. (890 aa)
A0A287AM45_PIGIg-like domain-containing protein. (282 aa)
PSME4Proteasome activator complex subunit 4. (1843 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
A0A287AU93_PIGIg-like domain-containing protein. (216 aa)
NFKB1Uncharacterized protein. (898 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
RASGRP3RAS guanyl releasing protein 3. (692 aa)
A0A287BAB3_PIGIg-like domain-containing protein. (169 aa)
STIM1Stromal interaction molecule 1. (791 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
A0A287BH28_PIGIg-like domain-containing protein. (185 aa)
A0A287BHK5_PIGIg-like domain-containing protein. (125 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
A0A287BLH9_PIGUncharacterized protein. (221 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PSMB1Proteasome subunit beta. (241 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
LAC_PIGIg lambda chain C region. (380 aa)
A0A287BNX9_PIGIg-like domain-containing protein. (111 aa)
A0A287BRE1_PIGIg-like domain-containing protein. (112 aa)
PSMB10Proteasome subunit beta. (296 aa)
PSMA7Proteasome subunit alpha type. (267 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
CD79AIg-like domain-containing protein. (234 aa)
A0A5G2Q8Z5_PIGIg-like domain-containing protein. (131 aa)
PSMA1Proteasome subunit alpha type. (269 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
PSMA2Proteasome endopeptidase complex. (243 aa)
BLNKB-cell linker protein isoform 1. (463 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (905 aa)
PSMA4Proteasome subunit alpha type. (281 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMA3Proteasome subunit alpha type. (275 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (419 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMB6Uncharacterized protein. (334 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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