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CDKN1A CDKN1A GSTA1 GSTA1 GSTA4 GSTA4 BAX BAX CASP9 CASP9 XPA XPA MGST3 MGST3 GSTM3 GSTM3 MSH2 MSH2 GSTT4 GSTT4 GSTO1 GSTO1 GSTO2 GSTO2 TOP2B TOP2B ATP7A ATP7A LOC100739163 LOC100739163 ATM ATM CYCS CYCS TOP2A TOP2A ERBB2 ERBB2 FASLG FASLG LOC100510917 LOC100510917 LOC100519295 LOC100519295 CASP8 CASP8 MLH1 MLH1 PMAIP1 PMAIP1 MSH6 MSH6 FADD FADD BAK1 BAK1 BCL2L1 BCL2L1 MAP3K5 MAP3K5 PDPK1 PDPK1 MGST1 MGST1 XIAP XIAP ATP7B ATP7B MSH3 MSH3 APAF1 APAF1 BIRC5 BIRC5 BAD BAD REV3L REV3L SLC31A1 SLC31A1 POLH POLH AKT2 AKT2 BID BID CASP3 CASP3 BIRC3 BIRC3 TP53 TP53 AKT1 AKT1 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 MDM2 MDM2 MAPK3 MAPK3 MGST2 MGST2 FAS FAS BBC3 BBC3 AKT3 AKT3 A0A5G2R4D9_PIG A0A5G2R4D9_PIG ABCC2 ABCC2 MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
GSTA1Glutathione S-transferase alpha M14, N-terminally processed; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (298 aa)
GSTA4Glutathione S-transferase alpha 4. (223 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (438 aa)
XPAXPA, DNA damage recognition and repair factor. (310 aa)
MGST3Microsomal glutathione S-transferase 3. (151 aa)
GSTM3Glutathione S-transferase. (225 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
GSTO1Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. (241 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1614 aa)
ATP7AATPase copper transporting alpha. (1507 aa)
LOC100739163Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity); Belongs to the GST superfamily. Pi family. (309 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TOP2ADNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. (1531 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
FASLGTumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] (282 aa)
LOC100510917Uncharacterized protein. (222 aa)
LOC100519295Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CASP8Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa)
MLH1DNA mismatch repair protein Mlh1 isoform 1. (757 aa)
PMAIP1Uncharacterized protein. (121 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1363 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
BAK1Uncharacterized protein. (266 aa)
BCL2L1Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1425 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
MGST1Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the MAPEG family. (155 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
ATP7BUncharacterized protein. (275 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1123 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
BIRC5Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa)
BADBCL2 associated agonist of cell death. (209 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3130 aa)
SLC31A1High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake. (189 aa)
POLHDNA polymerase eta. (698 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
BIDBH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
FASTumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa)
BBC3Uncharacterized protein. (361 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
A0A5G2R4D9_PIGGlutathione S-transferase. (348 aa)
ABCC2ATP binding cassette subfamily C member 2. (1541 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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