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PPARA PPARA OLR1 OLR1 RXRB RXRB PPARD PPARD ACSBG1 ACSBG1 LOC100522145 LOC100522145 FABP7 FABP7 SLC27A2 SLC27A2 PLTP PLTP FABP1 FABP1 SCD5 SCD5 ACAA1 ACAA1 PPARG PPARG CPT1A CPT1A FADS2 FADS2 NR1H3 NR1H3 PLIN4 PLIN4 ANGPTL4 ANGPTL4 ME3 ME3 CD36 CD36 ACADL ACADL HMGCS1 HMGCS1 FABP6 FABP6 ILK ILK ACSL5 ACSL5 EHHADH EHHADH PCK1 PCK1 APOA1 APOA1 CYP7A1 CYP7A1 SLC27A6 SLC27A6 HMGCS2 HMGCS2 ACOX1 ACOX1 PDPK1 PDPK1 FABP4 FABP4 FABP3 FABP3 CYP8B1 CYP8B1 FABP2 FABP2 CPT1C CPT1C PCK2 PCK2 ACOX2 ACOX2 ACSBG2 ACSBG2 CPT1B CPT1B ADIPOQ ADIPOQ SLC27A1 SLC27A1 DBI DBI ACSL3 ACSL3 AQP7 AQP7 SLC27A5 SLC27A5 ACSL4 ACSL4 LPL LPL ACSL6 ACSL6 RXRG RXRG PLIN5 PLIN5 UBC UBC ACOX3 ACOX3 APOC3 APOC3 PLIN1 PLIN1 SLC27A4 SLC27A4 APOA2 APOA2 CPT2 CPT2 RXRA RXRA ME1 ME1 PLIN2 PLIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAUncharacterized protein. (469 aa)
OLR1Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] (272 aa)
RXRBRetinoid X receptor beta. (536 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (709 aa)
LOC100522145Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
FABP7FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (166 aa)
SLC27A2Solute carrier family 27 (Fatty acid transporter) member 2. (620 aa)
PLTPPhospholipid transfer protein. (496 aa)
FABP1Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (151 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (332 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
FADS2Cytochrome b5 heme-binding domain-containing protein. (712 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (470 aa)
PLIN4Perilipin 4. (1655 aa)
ANGPTL4Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa)
ME3Malic enzyme. (604 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
ACADLLong-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] (430 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (576 aa)
FABP6Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (143 aa)
ILKIntegrin linked kinase. (479 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (705 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (841 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (279 aa)
CYP7A1Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...] (554 aa)
SLC27A6Solute carrier family 27 member 6. (655 aa)
HMGCS2Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (508 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
FABP4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Involved in the regulation of intramuscular fat accretion ; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
FABP3Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. (133 aa)
CYP8B15-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 5 beta-cholestane-3-alpha,7-alpha-diol into 5 beta- cholestane-3-alpha,7-alpha,12-alpha triol. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. (501 aa)
FABP2Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity). (132 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (732 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (681 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (674 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform. (807 aa)
ADIPOQC1q domain-containing protein. (332 aa)
SLC27A1Solute carrier family 27 (Fatty acid transporter), member 1. (646 aa)
DBIAcyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor; Belongs to the ACBP family. (88 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (729 aa)
AQP7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (336 aa)
SLC27A5Solute carrier family 27 member 5. (710 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans; Belongs to the AB hydrolase superfamily. Lipase family. (486 aa)
ACSL6Long-chain-fatty-acid--CoA ligase 6 isoform X1. (722 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
PLIN5Perilipin 5. (736 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (199 aa)
PLIN1Uncharacterized protein. (578 aa)
SLC27A4Solute carrier family 27 member 4. (673 aa)
APOA2Apolipoprotein A-II preproprotein. (100 aa)
CPT2Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
RXRARetinoid X receptor alpha. (701 aa)
ME1NADP-dependent malic enzyme; Belongs to the malic enzymes family. (571 aa)
PLIN2Perilipin-2; May be involved in development and maintenance of adipose tissue; Belongs to the perilipin family. (459 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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