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| | PPARA | Uncharacterized protein. (469 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa) |
| | LOC100737927 | Uncharacterized protein. (1486 aa) |
| | HCN4 | Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1199 aa) |
| | SSTR1 | Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa) |
| | GRIN2D | Glutamate ionotropic receptor NMDA type subunit 2D. (1332 aa) |
| | RRAS | RAS related. (218 aa) |
| | NPPA | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (818 aa) |
| | PTGER3 | Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal ur [...] (427 aa) |
| | VIP | Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (167 aa) |
| | CNGB3 | Cyclic nucleotide gated channel subunit beta 3. (774 aa) |
| | ADCY10 | Adenylate cyclase 10. (1610 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (395 aa) |
| | NPR1 | Guanylate cyclase. (1057 aa) |
| | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1028 aa) |
| | TSHB | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (138 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | OXT | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. (125 aa) |
| | CREBBP | CREB-binding protein isoform a. (2440 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa) |
| | DRD5 | Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (471 aa) |
| | NPY1R | Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (383 aa) |
| | EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) |
| | HCAR1 | Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (340 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (411 aa) |
| | ADRB1 | Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (516 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa) |
| | GHRL | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family. (118 aa) |
| | ATP2B2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1235 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1611 aa) |
| | GPR119 | G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa) |
| | CNGA2 | Cyclic nucleotide gated channel subunit alpha 2. (663 aa) |
| | RELA | Transcription factor p65 isoform 1. (573 aa) |
| | FSHB | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (493 aa) |
| | ARSI | Arylsulfatase family member I. (570 aa) |
| | CNGA4 | Cyclic nucleotide gated channel subunit alpha 4. (591 aa) |
| | FXYD2 | FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (65 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa) |
| | GCG | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (510 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa) |
| | GLI3 | GLI family zinc finger 3. (1586 aa) |
| | SSTR2 | Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 [...] (360 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa) |
| | PDE3A | Phosphodiesterase. (1145 aa) |
| | HTR1F | 5-hydroxytryptamine receptor 1F isoform X1. (366 aa) |
| | RAPGEF3 | Rap guanine nucleotide exchange factor 3 isoform a. (923 aa) |
| | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha. (1030 aa) |
| | GRIA4 | Glutamate ionotropic receptor AMPA type subunit 4. (884 aa) |
| | DRD1 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa) |
| | ADCY5 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa) |
| | HTR6 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa) |
| | GIP | Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Belongs to the glucagon family. (144 aa) |
| | POMC | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (381 aa) |
| | GRIN3B | Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1031 aa) |
| | SUCNR1 | Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa) |
| | GRIN2C | Glutamate ionotropic receptor NMDA type subunit 2C. (872 aa) |
| | PTGER2 | Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | PTCH1 | Protein patched homolog 1 isoform L. (1452 aa) |
| | GNAS-2 | Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa) |
| | ATP2B3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1193 aa) |
| | ATP1B4 | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity). (355 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (473 aa) |
| | GRIA3 | Glutamate ionotropic receptor AMPA type subunit 3. (894 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (546 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (373 aa) |
| | OXTR | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (374 aa) |
| | GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B. (1484 aa) |
| | CAMK4 | Calcium/calmodulin dependent protein kinase IV. (534 aa) |
| | AFDN | Afadin, adherens junction formation factor. (1815 aa) |
| | FFAR2 | Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1020 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (845 aa) |
| | SSTR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (305 aa) |
| | ATP1A3 | Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1287 aa) |
| | GRIA1 | Glutamate ionotropic receptor AMPA type subunit 1. (906 aa) |
| | ACOX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (660 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa) |
| | F2R | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (427 aa) |
| | RAP1B | RAP1B, member of RAS oncogene family. (184 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | PDE3B | Phosphodiesterase. (1117 aa) |
| | CFTR | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | ARAP3 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5. (1545 aa) |
| | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1042 aa) |
| | EDN2 | Endothelin 2. (180 aa) |
| | RRAS2 | Uncharacterized protein. (276 aa) |
| | ATP2B1 | Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa) |
| | LHB-2 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (173 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. (938 aa) |
| | HCAR2 | Hydroxycarboxylic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (363 aa) |
| | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa) |
| | NPY | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (169 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (325 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | ADCYAP1R1 | Pituitary adenylate cyclase-activating polypeptide type I receptor short form; Belongs to the G-protein coupled receptor 2 family. (468 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa) |
| | GRIA2 | Glutamate ionotropic receptor AMPA type subunit 2. (883 aa) |
| | RHOA | Transforming protein RhoA isoform 1. (193 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1171 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (525 aa) |
| | BDNF | Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (260 aa) |
| | HCN2 | Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (897 aa) |
| | CGA | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (144 aa) |
| | PDE4D | Phosphodiesterase. (809 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2316 aa) |
| | NFKB1 | Uncharacterized protein. (898 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa) |
| | CACNA1F | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1977 aa) |
| | ADRB2 | Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa) |
| | GRIN1 | Glutamate ionotropic receptor NMDA type subunit 1. (959 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (785 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | SST | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. (116 aa) |
| | PDE10A | Phosphodiesterase. (788 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CHRM2 | Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily. (466 aa) |
| | HHIP | Hedgehog-interacting protein. (700 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | TSHR | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (764 aa) |
| | ABCC4 | Multidrug resistance-associated protein 4 isoform X1. (1325 aa) |
| | LIPE | Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (1057 aa) |
| | ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). (176 aa) |
| | HTR1E | 5-hydroxytryptamine receptor 1E; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). (343 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PDE4C | Phosphodiesterase. (729 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa) |
| | ORAI1 | Uncharacterized protein. (408 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | GRIN2A | Glutamate ionotropic receptor NMDA type subunit 2A. (1464 aa) |
| | ADCY3 | Adenylate cyclase 3. (1320 aa) |
| | GRIN3A | Glutamate ionotropic receptor NMDA type subunit 3A. (1114 aa) |
| | AMH | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin (By similarity). (577 aa) |
| | PRKACB | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa) |
| | ROCK2 | Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa) |
| | GABBR2 | Gamma-aminobutyric acid type B receptor subunit 2. (958 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (670 aa) |
| | ACOX3 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (720 aa) |
| | HTR1B | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (405 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | HTR4 | 5-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. (407 aa) |
| | CNGA1 | Cyclic nucleotide gated channel subunit alpha 1. (737 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1028 aa) |
| | FFAR2-L | Free fatty acid receptor 2-like receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa) |
| | EDN3 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (231 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (874 aa) |
| | CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (214 aa) |
| | GLP1R | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (468 aa) |
| | HTR1D | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] (377 aa) |
| | RAC2 | Rac family small GTPase 2. (217 aa) |
| | GABBR1 | Gamma-aminobutyric acid type B receptor subunit 1. (1247 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa) |
| | CALML4 | Uncharacterized protein. (154 aa) |
| | RYR2 | Ryanodine receptor 2. (4966 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (879 aa) |
| | MYL9 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (176 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (520 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | LOC100153359 | Uncharacterized protein. (1156 aa) |
| | PDE4B | Phosphodiesterase. (736 aa) |
