STRINGSTRING
IRAK4 IRAK4 NFKBIA NFKBIA PLCG2 PLCG2 TRAF1 TRAF1 TRAF2 TRAF2 LY96 LY96 LYN LYN VCAM1 VCAM1 BCL10 BCL10 IKBKB IKBKB PLCG1 PLCG1 EDAR EDAR CXCL8 CXCL8 TNFSF11 TNFSF11 TNFSF13B TNFSF13B PLAU PLAU CHUK CHUK NFKB2 NFKB2 CCL19 CCL19 PRKCQ PRKCQ MYD88 MYD88 IRAK1 IRAK1 RELA RELA CD14 CD14 ATM ATM CARD14 CARD14 MAP3K14 MAP3K14 LBP LBP CD40LG CD40LG PARP1 PARP1 BTK BTK TICAM1 TICAM1 UBE2I UBE2I GADD45G GADD45G CSNK2B CSNK2B LTA LTA TAB1 TAB1 TRAF5 TRAF5 TNFRSF11A TNFRSF11A EDA EDA ICAM1 ICAM1 MALT1 MALT1 ZAP70 ZAP70 PIDD1 PIDD1 TNFAIP3 TNFAIP3 BCL2L1 BCL2L1 SYK SYK TRAF6 TRAF6 RELB RELB BCL2A1 BCL2A1 PTGS2 PTGS2 TNFRSF1A TNFRSF1A TICAM2 TICAM2 EDARADD EDARADD TAB2 TAB2 CCL21 CCL21 PRKCB PRKCB CFLAR CFLAR GADD45B GADD45B CARD11 CARD11 XIAP XIAP PIAS4 PIAS4 CYLD CYLD LCK LCK TRAF3 TRAF3 CSNK2A2 CSNK2A2 TNFRSF13C TNFRSF13C IL1B IL1B DDX58 DDX58 ERC1 ERC1 TIRAP TIRAP NFKB1 NFKB1 IKBKG IKBKG BIRC3 BIRC3 CXCL2 CXCL2 CD40 CD40 TRAV16 TRAV16 MAP3K7 MAP3K7 GADD45A GADD45A TRADD TRADD RIPK1 RIPK1 LTBR LTBR TAB3 TAB3 TLR4 TLR4 BLNK BLNK CSNK2A1 CSNK2A1 TNFSF14 TNFSF14 CXCL12 CXCL12 CCL4 CCL4 IL1R1 IL1R1 TRIM25 TRIM25 A0A5G2R5H2_PIG A0A5G2R5H2_PIG CARD10 CARD10 LOC110261595 LOC110261595
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRAK4Protein kinase domain-containing protein. (459 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TRAF1TNF receptor-associated factor. (415 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
LY96Lymphocyte antigen 96 isoform 1. (160 aa)
LYNTyrosine-protein kinase. (512 aa)
VCAM1Uncharacterized protein. (537 aa)
BCL10B-cell lymphoma/leukemia 10 isoform 1. (233 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
EDAREctodysplasin A receptor. (461 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (233 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (901 aa)
CCL19C-C motif chemokine. (100 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (691 aa)
RELATranscription factor p65 isoform 1. (573 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa)
CARD14Caspase recruitment domain family member 14. (733 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (930 aa)
LBPUncharacterized protein. (586 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
BTKTyrosine-protein kinase. (659 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (713 aa)
UBE2IUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (409 aa)
GADD45GGrowth arrest and DNA-damage-inducible gamma protein. (159 aa)
CSNK2BCasein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (204 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (604 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
TNFRSF11ATNF receptor superfamily member 11a. (629 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (389 aa)
ICAM1Intercellular adhesion molecule 1. (537 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
ZAP70Tyrosine-protein kinase. (615 aa)
PIDD1P53-induced death domain protein 1. (954 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (785 aa)
BCL2L1Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
BCL2A1Bcl-2-related protein A1 isoform 1. (175 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
TICAM2TIR domain-containing adapter molecule 2. (237 aa)
EDARADDEDAR associated death domain. (207 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (692 aa)
CCL21Putative CCL21 chemokine. (134 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (509 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
PIAS4Protein inhibitor of activated STAT 4. (566 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa)
LCKTyrosine-protein kinase. (520 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
CSNK2A2Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily. (350 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C. (186 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa)
DDX58Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1092 aa)
TIRAPTIR domain containing adaptor protein. (243 aa)
NFKB1Uncharacterized protein. (898 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
CXCL2C-X-C motif chemokine. (107 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
TRAV16T cell receptor alpha variable 16. (166 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (184 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (304 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
LTBRUncharacterized protein. (432 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (841 aa)
BLNKB-cell linker protein isoform 1. (463 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform 1. (241 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
IL1R1Interleukin-1 receptor type 1 isoform 1. (572 aa)
TRIM25Tripartite motif containing 25. (633 aa)
A0A5G2R5H2_PIGUncharacterized protein. (261 aa)
CARD10Caspase recruitment domain family member 10. (1244 aa)
LOC110261595Ig-like domain-containing protein. (290 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.