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PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (639 aa) | ||||
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) | ||||
ITPKC | Kinase; Belongs to the inositol phosphokinase (IPK) family. (754 aa) | ||||
PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) | ||||
PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa) | ||||
PIP4P2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) | ||||
PI4KB | Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (841 aa) | ||||
PLCG1 | Phosphoinositide phospholipase C. (1379 aa) | ||||
IPPK | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (549 aa) | ||||
INPP4A | Inositol polyphosphate-4-phosphatase type I A. (976 aa) | ||||
PTEN | Uncharacterized protein. (576 aa) | ||||
PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha. (479 aa) | ||||
INPP5F | Phosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa) | ||||
INPP5A | Inositol polyphosphate-5-phosphatase A. (472 aa) | ||||
PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa) | ||||
CALML5 | Calmodulin like 5. (149 aa) | ||||
IP6K1 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa) | ||||
MTMR14 | Myotubularin related protein 14. (728 aa) | ||||
DGKK | Diacylglycerol kinase. (1266 aa) | ||||
PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa) | ||||
INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa) | ||||
MTMR2 | Myotubularin-related protein 2 isoform 1. (643 aa) | ||||
PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) | ||||
INPP1 | Inositol polyphosphate 1-phosphatase isoform X1. (402 aa) | ||||
DGKD | Diacylglycerol kinase. (1244 aa) | ||||
PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) | ||||
PLCD3 | Phosphoinositide phospholipase C. (784 aa) | ||||
DGKE | Diacylglycerol kinase. (566 aa) | ||||
MTMR4 | Myotubularin related protein 4. (1205 aa) | ||||
SYNJ2 | Synaptojanin 2. (1402 aa) | ||||
DGKG | Diacylglycerol kinase. (791 aa) | ||||
MTMR8 | Myotubularin-related protein 8. (692 aa) | ||||
PI4K2B | Phosphatidylinositol 4-kinase type 2 beta. (598 aa) | ||||
PIK3C2A | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa) | ||||
ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa) | ||||
PIK3C2G | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1511 aa) | ||||
IMPA1 | Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta- glycerophosphate, and 2'-AMP as substrates. (363 aa) | ||||
MTMR1 | Myotubularin related protein 1. (671 aa) | ||||
MTM1 | Myotubularin isoform X3. (603 aa) | ||||
PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa) | ||||
PI4KA | Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2072 aa) | ||||
SYNJ1 | Synaptojanin 1. (1576 aa) | ||||
PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) | ||||
CDS1 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (472 aa) | ||||
DGKZ | Diacylglycerol kinase. (1144 aa) | ||||
PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) | ||||
PPIP5K1 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1523 aa) | ||||
IMPAD1 | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa) | ||||
INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa) | ||||
IP6K3 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (409 aa) | ||||
DGKI | Diacylglycerol kinase. (1110 aa) | ||||
DGKA | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa) | ||||
MTMR7 | Myotubularin related protein 7. (659 aa) | ||||
PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa) | ||||
DGKH | Diacylglycerol kinase. (1222 aa) | ||||
PLCE1 | Phosphoinositide phospholipase C. (2316 aa) | ||||
DGKB | Diacylglycerol kinase. (802 aa) | ||||
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) | ||||
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) | ||||
LOC100511937 | Uncharacterized protein. (532 aa) | ||||
PIKFYVE | Phosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa) | ||||
ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (650 aa) | ||||
IPMK | Kinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa) | ||||
CDS2 | Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (455 aa) | ||||
INPP4B | Inositol polyphosphate-4-phosphatase type II B. (938 aa) | ||||
ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa) | ||||
MTMR3 | Myotubularin related protein 3. (1215 aa) | ||||
PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) | ||||
IP6K2 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa) | ||||
SACM1L | SAC1 like phosphatidylinositide phosphatase. (596 aa) | ||||
DGKQ | Diacylglycerol kinase. (987 aa) | ||||
ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa) | ||||
PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa) | ||||
PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa) | ||||
OCRL | OCRL inositol polyphosphate-5-phosphatase. (903 aa) | ||||
CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (214 aa) | ||||
PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa) | ||||
INPP5E | Inositol polyphosphate-5-phosphatase E. (829 aa) | ||||
CALML4 | Uncharacterized protein. (154 aa) | ||||
PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa) | ||||
PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa) | ||||
CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa) |