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PLCZ1 PLCZ1 PLCG2 PLCG2 ITPKC ITPKC PRKCG PRKCG PIK3C3 PIK3C3 PIP4P2 PIP4P2 PI4KB PI4KB PLCG1 PLCG1 IPPK IPPK INPP4A INPP4A PTEN PTEN PI4K2A PI4K2A INPP5F INPP5F INPP5A INPP5A PIP4K2A PIP4K2A CALML5 CALML5 IP6K1 IP6K1 MTMR14 MTMR14 DGKK DGKK PLCB3 PLCB3 INPPL1 INPPL1 MTMR2 MTMR2 PIK3C2B PIK3C2B INPP1 INPP1 DGKD DGKD PRKCA PRKCA PLCD3 PLCD3 DGKE DGKE MTMR4 MTMR4 SYNJ2 SYNJ2 DGKG DGKG MTMR8 MTMR8 PI4K2B PI4K2B PIK3C2A PIK3C2A ITPR2 ITPR2 PIK3C2G PIK3C2G IMPA1 IMPA1 MTMR1 MTMR1 MTM1 MTM1 PIP4P1 PIP4P1 PI4KA PI4KA SYNJ1 SYNJ1 PRKCB PRKCB CDS1 CDS1 DGKZ DGKZ PLCB4 PLCB4 PPIP5K1 PPIP5K1 IMPAD1 IMPAD1 INPP5D INPP5D IP6K3 IP6K3 DGKI DGKI DGKA DGKA MTMR7 MTMR7 PIP5K1C PIP5K1C DGKH DGKH PLCE1 PLCE1 DGKB DGKB PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 PIKFYVE PIKFYVE ITPKB ITPKB IPMK IPMK CDS2 CDS2 INPP4B INPP4B ITPR3 ITPR3 MTMR3 MTMR3 PLCB2 PLCB2 IP6K2 IP6K2 SACM1L SACM1L DGKQ DGKQ ITPR1 ITPR1 PIP5K1B PIP5K1B PLCB1 PLCB1 OCRL OCRL CALM3 CALM3 PIP5K1A PIP5K1A INPP5E INPP5E CALML4 CALML4 PIP4K2C PIP4K2C PIP4K2B PIP4K2B CDIPT CDIPT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (639 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (754 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (841 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (549 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (976 aa)
PTENUncharacterized protein. (576 aa)
PI4K2APhosphatidylinositol 4-kinase type 2-alpha. (479 aa)
INPP5FPhosphatidylinositide phosphatase SAC2 isoform 1. (1133 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (472 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] (442 aa)
CALML5Calmodulin like 5. (149 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
MTMR14Myotubularin related protein 14. (728 aa)
DGKKDiacylglycerol kinase. (1266 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa)
MTMR2Myotubularin-related protein 2 isoform 1. (643 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
INPP1Inositol polyphosphate 1-phosphatase isoform X1. (402 aa)
DGKDDiacylglycerol kinase. (1244 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
DGKEDiacylglycerol kinase. (566 aa)
MTMR4Myotubularin related protein 4. (1205 aa)
SYNJ2Synaptojanin 2. (1402 aa)
DGKGDiacylglycerol kinase. (791 aa)
MTMR8Myotubularin-related protein 8. (692 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (598 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1669 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1511 aa)
IMPA1Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta- glycerophosphate, and 2'-AMP as substrates. (363 aa)
MTMR1Myotubularin related protein 1. (671 aa)
MTM1Myotubularin isoform X3. (603 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2072 aa)
SYNJ1Synaptojanin 1. (1576 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (472 aa)
DGKZDiacylglycerol kinase. (1144 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1523 aa)
IMPAD1Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] (359 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (409 aa)
DGKIDiacylglycerol kinase. (1110 aa)
DGKADiacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa)
MTMR7Myotubularin related protein 7. (659 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa)
DGKHDiacylglycerol kinase. (1222 aa)
PLCE1Phosphoinositide phospholipase C. (2316 aa)
DGKBDiacylglycerol kinase. (802 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2055 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (650 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (455 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (938 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
MTMR3Myotubularin related protein 3. (1215 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (596 aa)
DGKQDiacylglycerol kinase. (987 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (903 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (829 aa)
CALML4Uncharacterized protein. (154 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (529 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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