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| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | RRAGC | Ras related GTP binding C. (440 aa) |
| | CEP192 | Centrosomal protein 192. (2799 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | RNF152 | E3 ubiquitin-protein ligase RNF152 isoform X1. (203 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | RPS6 | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa) |
| | RRAGA | Ras related GTP binding A. (313 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | ATP6V1C1 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (397 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin- coated pits, required for the formation of endosomes (By similarity). (483 aa) |
| | LAMTOR2 | Ragulator complex protein LAMTOR2 isoform 1. (125 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa) |
| | IKBKB | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa) |
| | TTI1 | TELO2 interacting protein 1. (1087 aa) |
| | WDR24 | GATOR complex protein WDR24. (790 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (455 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (395 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) |
| | ATP6V1C2 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (438 aa) |
| | CAB39L | Calcium binding protein 39 like. (337 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1. (409 aa) |
| | PTEN | Uncharacterized protein. (576 aa) |
| | CHUK | Protein kinase domain-containing protein. (580 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | EIF4E1B | Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa) |
| | FNIP1 | Folliculin interacting protein 1. (1061 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa) |
| | CAB39 | Calcium-binding protein 39. (341 aa) |
| | EIF4E2 | Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (247 aa) |
| | ATP6V1F | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa) |
| | SKP2 | S-phase kinase-associated protein 2 isoform 1. (436 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa) |
| | EIF4EBP1 | Uncharacterized protein. (182 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (794 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1351 aa) |
| | ATP6V1B2 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (508 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa) |
| | SLC3A2 | Solute carrier family 3 member 2. (562 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | PRR5 | Proline rich 5. (386 aa) |
| | MIOS | Meiosis regulator for oocyte development. (877 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | RRAGB | Ras-related GTP-binding protein B long isoform. (374 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | EIF4E | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (237 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ATP6V1G2 | V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | GRB10 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa) |
| | RRAGD | Ras-related GTP-binding protein D. (396 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | LPIN2 | Lipin 2. (937 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (526 aa) |
| | STRADA | STE20 related adaptor alpha. (432 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (668 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa) |
| | FNIP2 | Folliculin-interacting protein 2 isoform X3. (1163 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa) |
| | MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1 isoform 1. (522 aa) |
| | WDR59 | WD repeat domain 59. (938 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa) |
| | DDIT4 | Uncharacterized protein. (231 aa) |
| | DEPDC5 | DEP domain-containing protein. (1593 aa) |
| | TELO2 | Telomere length regulation protein TEL2 homolog isoform X1. (952 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa) |
| | ATP6V1E1 | ATPase H+ transporting V1 subunit E1. (224 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | RHOA | Transforming protein RhoA isoform 1. (193 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (525 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa) |
| | CASTOR2 | Uncharacterized protein. (314 aa) |
| | LAMTOR3 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (785 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | ATP6V1A | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (618 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LAMTOR5 | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] (229 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | TSC2 | TSC complex subunit 2. (1836 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1789 aa) |
| | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | TBC1D7 | TBC1 domain family member 7 isoform X1. (293 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | ATP6V1G3 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | ATP6V1E2 | ATPase H+ transporting V1 subunit E2. (301 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | STRADB | STE20 related adaptor beta. (430 aa) |
| | ATP6V1D | ATPase H+ transporting V1 subunit D. (250 aa) |
| | SESN2 | Sestrin 2. (471 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (611 aa) |
| | DEPTOR | DEP domain-containing mTOR-interacting protein isoform 1. (409 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | AKT1S1 | AKT1 substrate 1. (323 aa) |
| | LPIN1 | Lipin 1. (957 aa) |
| | LAMTOR4 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4. (100 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (744 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa) |
| | TSC1 | TSC complex subunit 1. (1166 aa) |
| | SEC13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (341 aa) |
| | LAMTOR1 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (204 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | RHEB | Uncharacterized protein. (220 aa) |
