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LOC100157935 LOC100157935 HRC HRC CACNG6 CACNG6 SLC9A1 SLC9A1 LOC100524873 LOC100524873 COX7A2 COX7A2 ACTC1 ACTC1 ATP1A1 ATP1A1 UQCRC2 UQCRC2 COX5B COX5B MYL3 MYL3 CACNA1D CACNA1D COX8A COX8A LOC100524239 LOC100524239 UQCRQ UQCRQ FXYD2 FXYD2 CACNG1 CACNG1 MYL4 MYL4 ATP1B2 ATP1B2 COX1 COX1 COX2 COX2 COX3 COX3 CYTB CYTB COX5A COX5A ATP1A4 ATP1A4 CACNG7 CACNG7 CACNA2D4 CACNA2D4 UQCRFS1 UQCRFS1 TNNT2 TNNT2 UQCR10 UQCR10 ATP1B4 ATP1B4 CACNG4 CACNG4 SLC8A2 SLC8A2 CACNA2D2 CACNA2D2 CACNB3 CACNB3 ATP2A3 ATP2A3 ATP1A3 ATP1A3 MYL2 MYL2 ATP2A2 ATP2A2 CACNG2 CACNG2 COX4I2 COX4I2 COX6B COX6B TPM4 TPM4 CACNA1C CACNA1C CACNA2D3 CACNA2D3 TPM2 TPM2 COX6A2 COX6A2 ATP1B1 ATP1B1 CACNB4 CACNB4 TNNC1 TNNC1 SLC9A7 SLC9A7 ATP2A1 ATP2A1 CACNB2 CACNB2 COX6B2 COX6B2 COX7A1 COX7A1 COX7C COX7C CACNA1F CACNA1F CACNG5 CACNG5 CACNG3 CACNG3 CYC1 CYC1 CACNA2D1 CACNA2D1 SLC8A3 SLC8A3 COX6A1 COX6A1 COX7B COX7B SLC8A1 SLC8A1 TRDN TRDN MYH7 MYH7 RYR2 RYR2 SLC9A6 SLC9A6
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC100157935Uncharacterized protein. (70 aa)
HRCSarcoplasmic reticulum histidine-rich calcium-binding protein. (620 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (259 aa)
SLC9A1Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (818 aa)
LOC100524873Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
COX7A2Uncharacterized protein. (115 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1028 aa)
UQCRC2Cytochrome b-c1 complex subunit 2, mitochondrial; Belongs to the peptidase M16 family. (453 aa)
COX5BCytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (129 aa)
MYL3Uncharacterized protein. (196 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa)
COX8ACytochrome c oxidase subunit 8A, mitochondrial. (69 aa)
LOC100524239Cytochrome b-c1 complex subunit 10. (56 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (65 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (224 aa)
MYL4Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. (197 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (289 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (229 aa)
COX3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa)
COX5ACytochrome c oxidase subunit 5A, mitochondrial. (152 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1114 aa)
UQCRFS1Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1. (295 aa)
TNNT2Uncharacterized protein. (295 aa)
UQCR10Ubiquinol-cytochrome c reductase complex. (64 aa)
ATP1B4Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity). (355 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (326 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1002 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1068 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform 1. (484 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1020 aa)
ATP1A3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1287 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1042 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
COX4I2Cytochrome c oxidase subunit 4I2. (171 aa)
COX6BCytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
TPM4Tropomyosin alpha-4 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. (284 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1092 aa)
TPM2Uncharacterized protein; Belongs to the tropomyosin family. (359 aa)
COX6A2Cytochrome c oxidase subunit 6A, mitochondrial. (97 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (325 aa)
CACNB4SH3 domain-containing protein. (519 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (184 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (732 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (656 aa)
COX6B2Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
COX7A1Cytochrome c oxidase subunit 7A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] (80 aa)
COX7CCytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (63 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1977 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (303 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
CYC1Cytochrome c1, heme protein, mitochondrial. (326 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1110 aa)
SLC8A3Sodium/calcium exchanger 3 isoform A; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
COX6A1Cytochrome c oxidase subunit 6A, mitochondrial. (109 aa)
COX7BCytochrome c oxidase subunit 7B, mitochondrial. (80 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
TRDNTriadin. (729 aa)
MYH7Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
RYR2Ryanodine receptor 2. (4966 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (679 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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